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Obtusifolin

Cat. No. M4685

All AbMole products are for research use only, cannot be used for human consumption.

Obtusifolin Structure
Size Price Availability Quantity
1mg USD 75  USD75 In stock
5mg USD 215  USD215 In stock
10mg USD 310  USD310 In stock
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Quality Control & Documentation
Biological Activity

Obtusifolin, a new coumarin from roots of Haplophyllum obtusifolium, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein.

Chemical Information
Molecular Weight 284.26
Formula C16H12O5
CAS Number 477-85-0
Solubility (25°C) DMSO 6 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jiho Nam, et al. Obtusifolin, an Anthraquinone Extracted from Senna obtusifolia (L.) H.S.Irwin & Barneby, Reduces Inflammation in a Mouse Osteoarthritis Model

[2] Zhu Huang, et al. Pharmacokinetics and tissue distribution study of obtusifolin in rats by liquid chromatography-tandem mass spectrometry

[3] Byung-Soo Choi, et al. Obtusifolin isolated from the seeds of Cassia obtusifolia regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via affecting NF-κB pathway

[4] Yu Tang, et al. Obtusifolin inhibits high glucose‑induced mitochondrial apoptosis in human umbilical vein endothelial cells

[5] Yu Tang, et al. Obtusifolin treatment improves hyperlipidemia and hyperglycemia: possible mechanism involving oxidative stress

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Keywords: Obtusifolin supplier, NF-κB, inhibitors, activators

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