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Ethacrynic acid is non sulfonamide loop diuretic that is used to treat high blood pressure and the swelling caused by diseases like congestive heart failure. Ethacrynic acid blocks sodium-potassium-chloride cotransport. Also, Ethacrynic acid potently inhibits glutathione S-transferase family members. Studies show that ethacrynic acid potently inhibits Tgase-2 (transglutaminase-2) dependent metastasis of cancer cells including lung and pancreatic cancers.
| Molecular Weight | 303.14 |
| Formula | C13H12Cl2O4 |
| CAS Number | 58-54-8 |
| Solubility (25°C) | DMSO 60 mg/mL Water 15 mg/mL |
| Storage | 2-8°C, protect from light |
[1] K W Hinchcliff, et al. Furosemide, bumetanide, and ethacrynic acid
[3] No authors listed. JAMA. Ethacrynic acid
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