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Ethacrynic acid

Cat. No. M8436
Ethacrynic acid Structure
Size Price Availability Quantity
50mg USD 70  USD70 In stock
100mg USD 120  USD120 In stock
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Quality Control & Documentation
Biological Activity

Ethacrynic acid is non sulfonamide loop diuretic that is used to treat high blood pressure and the swelling caused by diseases like congestive heart failure. Ethacrynic acid blocks sodium-potassium-chloride cotransport. Also, Ethacrynic acid potently inhibits glutathione S-transferase family members. Studies show that ethacrynic acid potently inhibits Tgase-2 (transglutaminase-2) dependent metastasis of cancer cells including lung and pancreatic cancers.

Chemical Information
Molecular Weight 303.14
Formula C13H12Cl2O4
CAS Number 58-54-8
Solubility (25°C) DMSO: 20 mg/mL
Storage 2-8°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] K W Hinchcliff, et al. Furosemide, bumetanide, and ethacrynic acid

[2] J H Ploemen, et al. Ethacrynic acid and its glutathione conjugate as inhibitors of glutathione S-transferases

[3] No authors listed. JAMA. Ethacrynic acid

[4] No authors listed. Br Med J. Ethacrynic acid

[5] G C Urbinati. Ethacrynic acid

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