All AbMole products are for research use only, cannot be used for human consumption.
Betulinic acid is a natural pentacyclic triterpenoid compound, which is an inhibitor of eukaryotic cell topoisomerase I with IC50 value of 5 μM. It has anti-inflammatory, anti-malaria, anti-AIDS and anti-tumor activities. Betulinic acid(Betulinic acid) is also an agonist of 20S proteasome. EC50=5.5μmol/L, Betulinic acid can specifically enhance cT-L activity of 20S proteasome.
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Betulinic acid purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | H9 lymphocytes |
| Preparation method | Incubating H9 lymphocytes ( 1 ×107 cells/ml) in the presence or absence of HIV-1 (IIIB isolate) for 1 h at 37 °C. Washing cells thoroughly to remove unadsorbed virions and resuspending in culture medium. Adding betulinic acid (diluted in test medium) to the culture medium. After incubation for 3 days at 37 °C, the cell densities of uninfected cultures are determined to assess toxicity of betulinic acid. Using a p24 antigen capture assay to determine the level of HIV infection in HIV-treated culture |
| Concentrations | |
| Incubation time | 3 days |
| Animal Experiment | |
|---|---|
| Animal models | LNCaP tumor xenograft model |
| Formulation | Diluted in corn oil containing 1% DMSO |
| Dosages | 10 and 20 mg/kg/d |
| Administration | Orally |
| Molecular Weight | 456.7 |
| Formula | C30H48O3 |
| CAS Number | 472-15-1 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage | 2-8°C, protect from light, sealed |
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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