Sodium diethyldithiocarbamate trihydrate is a chelating agent, generally used in mobilizing toxic metals from the human tissues and experimental animals. Sodium diethyldithiocarbamate trihydrate inhibits induction of macrophage nitric oxide synthase.
Sodium diethyldithiocarbamate (DIECA) has been used as a JA biosynthesis inhibitor in plants and likely inhibits the JA pathway by shunting 13(S)-hydroperoxylinolenic acid to 13-hydroxylinolenic, thereby sharply reducing the precursor pool leading to cyclization and eventual synthesis of JA.
Sodium diethyldithiocarbamate trihydrate was used during the synthesis of N-allylpeptides.
Application: Spin trap used in conjunction with Fe2+ to detect NO in brain, kidney, liver, and other tissues. Simultaneous direct measurement of NO* and pO2 has been reported. A copper chelator, it has been used to quantitate copper in biological materials by ESR and is an inhibitor of superoxide dismutase, ascorbate oxidase, and other enzymes.
| Molecular Weight | 225.31 |
| Formula | (C2H5)2NCSSNa · 3H2O |
| CAS Number | 20624-25-3 |
| Solubility (25°C) | Water 100 mg/mL |
| Storage | RT, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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