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Berbamine dihydrochloride

Cat. No. M9456
Berbamine dihydrochloride Structure
Synonym:

Berbamine 2HCl

Size Price Availability Quantity
20mg USD 45  USD45 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Berbamine dihydrochloride is a novel inhibitor of NF-κB, inhibits growth and induces apoptosis in human myeloma cells. Berbamine inhibits the growth of KM3 cells in a dose- and time-dependent manner, and the IC50 values are 8.17 μg/mL, 5.09 μg/mL, and 3.84 μg/mL for treatment of 24, 48, and 72 h, respectively. The oral Berbamine treatment greatly suppresses the growth of Huh7 xenografted tumors over the time and leads to a tumor reduction by 70% based on the tumor weight.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 681.65
Formula C37H40N2O6.2HCl
CAS Number 6078-17-7
Purity >98%
Solubility Soluble in DMSO
hot water
Storage 2-8°C, dry, protect from light, sealed
References

[1] Yu Jin Kim, et al. Antiangiogenic and antitumor potential of berbamine, a natural CaMKIIγ inhibitor, against glioblastoma

[2] Chenglin Han, et al. Berbamine Suppresses the Progression of Bladder Cancer by Modulating the ROS/NF- κ B Axis

[3] Alexandria M Hudson, et al. Berbamine Analogs Exhibit Differential Protective Effects From Aminoglycoside-Induced Hair Cell Death

[4] Heng Zhang, et al. Berbamine suppresses cell proliferation and promotes apoptosis in ovarian cancer partially via the inhibition of Wnt/β-catenin signaling

[5] Heng Zhang, et al. Berbamine suppresses cell viability and induces apoptosis in colorectal cancer via activating p53-dependent apoptotic signaling pathway

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  Catalog
Abmole Inhibitor Catalog




Keywords: Berbamine dihydrochloride, Berbamine 2HCl supplier, NF-κB, inhibitors

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