Free shipping on all orders over $ 500
Berbamine dihydrochloride is a novel inhibitor of NF-κB, inhibits growth and induces apoptosis in human myeloma cells. Berbamine inhibits the growth of KM3 cells in a dose- and time-dependent manner, and the IC50 values are 8.17 μg/mL, 5.09 μg/mL, and 3.84 μg/mL for treatment of 24, 48, and 72 h, respectively. The oral Berbamine treatment greatly suppresses the growth of Huh7 xenografted tumors over the time and leads to a tumor reduction by 70% based on the tumor weight.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Molecular Weight | 681.65 |
| Formula | C37H40N2O6.2HCl |
| CAS Number | 6078-17-7 |
| Purity | >98% |
| Solubility | Soluble in DMSO hot water |
| Storage | 2-8°C, dry, protect from light, sealed |
| Related NF-κB Products |
|---|
| Dehydroevodiamine
Dehydroevodiamine has an antiarrhythmic effect in guinea-pig ventricular myocytes. Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells. |
| SN50
SN50 is a cell permeable inhibitor of NF-κB translocation. |
| NIK SMI1
NIK SMI1 is a highly selective and potent NF-κB-inducing kinase (NIK) inhibitor. |
| Helenalin
Helenalin is an anti-inflammatory sesquiterpene lactone, it selectively inhibits transcription factor NF-κB by directly targeting p65. |
| Licochalcone D
Licochalcone D is a potent inhibitor of NF-kappaB (NF-κB) p65 with antioxidant, anti-inflammatory, anti-cancer properties. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.
