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SN50

Cat. No. M10545
SN50 Structure
Size Price Availability Quantity
1mg USD 112  USD112 In stock
5mg USD 440  USD440 In stock
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Quality Control
  • Current batch:
  • Purity >98.5%
  • COA
  • MSDS
Biological Activity

SN50 is a cell permeable inhibitor of NF-κB translocation. SN50 suppresses nuclear factor-κB activation in local cells and reduces the incidence of epithelial defects/ulceration in healing corneas. SN50 can inhibit translocation of NF-kB and production of inflammatory cytokines that are implicated in lipopolysaccharide (LPS)-induced lung injury.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 2781.5
Formula C129H230N36O29S
CAS Number 213546-53-3
Purity >98.5%
Solubility Water 50 mg/mL
Storage -20°C, sealed
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SN50 supplier, NF-κB, inhibitors

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