About 31 results found for searched term "SN50" (0.221 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M10545 | SN50 | NF-κB |
| SN50 is a cell permeable inhibitor of NF-κB translocation. | ||
| M20957 | Cevimeline | AChR/AChE |
| AF 102B; SNI 2011; SNK 508 | ||
| Cevimeline (AF 102B, SNI 2011, SNK 508) is a parasympathomimetic agent that act as an agonist at the muscarinic acetylcholine receptors M1 and M3. | ||
| M25493 | MSN-50 | Bcl-2 |
| MSN50 | ||
| MSN-50 is a Bax and Bak oligomerization inhibitor. MSN-50 efficiently inhibits liposome permeabilization, prevents genotoxic cell death and promotes neuroprotection. | ||
| M50453 | SN50M | Others |
| SN50M, a mutant peptide of SN50, is a cell membrane-permeable inactive control peptide. | ||
| M2065 | SNS-032 | CDK |
| BMS-387032 | ||
| SNS-032 (BMS-387032) is a potent and selective inhibitor of CDK 9, 2 and 7 with IC50 values of 4, 38 and 62 nM respectively. | ||
| M3677 | N6022 | Others |
| N6022 is a potent, selective, reversible, and efficacious S-Nitrosoglutathione reductase(GSNOR) inhibitor(IC50=10 nM) which is currently undergoing clinical development. | ||
| M3701 | SNS-314 Mesylate | Aurora Kinase |
| SNS314 Mesylate | ||
| SNS-314 Mesylate is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. | ||
| M3771 | PSN632408 | GPR/FFAR |
| PSN632408 is a novel, selective and small-molecule agonist of human and mouse GPR119 with EC50 values of 5.6±0.99 μM and 7.9±0.7 μM, respectively. | ||
| M3773 | PSN-375963 | GPR/FFAR |
| PSN 375963 is an effective GPR119 agonist with EC50 of 8.4 and 7.9 μM for human and mice, respectively. PSN 375963 showed similar potency to endogenous oleoylethanolamide (OEA). | ||
| M7314 | SNC 80 | Opioid Receptor |
| NIH 10815; SNC80 | ||
| SNC 80 is a highly selective non-peptide δ-opioid receptor agonist with a Ki of 1.78 nM and an IC50 of 2.73 nM. | ||
| M7537 | SNS-314 | Aurora Kinase |
| SNS314 | ||
| SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively and less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. | ||
| M8488 | Ophiopogonin D' | Sirtuin |
| Ophiopogonin D', isolated from the tuber of Ophiopogon japonicus, is a rare naturally occurring C29 steroid glycoside. Ophiopogonin D' has cytotoxic activity against two human tumor cell lines mG-63 and SNU387. Ophiopogonin D' can induce necrotic apoptosis of prostate cancer LNCaP cells by activating RIPK1. IC50 were 3.09 μM and 3.63 μM, respectively. SIRT1 is activated in a dose-dependent manner by Ophiopogonin D'. | ||
| M8622 | TVB-3166 | FAS |
| TVB3166 | ||
| TVB-3166 is a cell-permeable pyrrazole derivative that inhibits cellular palmitate synthesis (IC50 <100 nM) by fatty acid synthase (FASN) keto-reductase activity in a potent and reversible manner (IC50 = 42 nM), effectively inhibiting palmitate-dependent survival of various cancer cells in cultures and xenografted tumor growth in mice vivo (60-100 mg/kg/d p. | ||
| M9130 | LSN3154567 | NAMPT |
| Nampt-IN-1 | ||
| LSN3154567 (also known as Nampt-IN-1) is a potent and elective NAMPT inhibitor, inhibits purified NAMPT with an IC50 of 3.1 nM. | ||
| M9681 | JBSNF-000088 (6-Methoxynicotinamide) | Others |
| 6-Methoxynicotinamide | ||
| Jbsnf-000088 (6-methoxynicotinamide) is a niacinamide (NA) analogue, which is a potent NNMT inhibitor. Jbsnf-000088 (6-methoxynicotinamide) is a niacinamide n-methyl transferase (NNMT) inhibitor. The IC50 of monkey NNMT and mouse NNMT were 1.8 µM, 2.8 µM and 5.0 µM, respectively. In animal models of metabolic diseases, JBSNF-000088 inhibits NNMT activity, reduces MNA levels and drives insulin sensitization and regulates glucose. | ||
| M10740 | Gusacitinib | JAK |
| ASN-002 | ||
| Gusacitinib (ASN-002) is a potent dual inhibitor of SYK kinase and JAK kinase,IC50 Values are 5-46 nM. Gusacitinib has anti-cancer activity in both solid and hematological tumors. | ||
| M10746 | Denifanstat | FAS |
| TVB-2640; FASN-IN-2; ASC-40 | ||
| Denifanstat (TVB-2640) is an orally potent selective FASN inhibitor.IC50 to 0.052 μM,EC50 is 0.072 μM. Denifanstat has the potential to be used in fatty liver and cancer research. | ||
| M10896 | Vecabrutinib | BTK |
| SNS-062 | ||
| Vecabrutinib (SNS-062) is a potent, non-covalent BTK and ITK inhibitor,Kd The values are 0.3 nM and 2.2 nM, respectively. Vecabrutinib for ITK IC50 The value is 24 nM. | ||
| M11322 | JBSNF-000088 | Others |
| 6-Methoxynicotinamide | ||
| Jbsnf-000088 (6-methoxynicotinamide) is an analogue of Nicotinamide (NA), and is an effective inhibitor of Nicotinamide n-methyltransferase (NNMT). The IC50 values for human NNMT(hNNMT), Monkey NNMT(mkNNMT) and mouse NNMT(mNNMT) were 1.8 µM, 2.8 µM and 5.0 µM. | ||
| M14297 | Fidarestat | Others |
| SNK 860 | ||
| Fidarestat (SNK 860) is an inhibitor of aldose reductase, with IC50s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively; Fidarestat (SNK 860) has the potential to treat diabetic disease. | ||
| M14432 | FASN-IN-4 tosylate | FAS |
| FASN-IN-4 tosylate is a potent inhibitor of fatty acid synthase (FASN) with an IC50 of 10 nM (WO2012064642A1, compound 29). FASN-IN-4 tosylate also inhibits SARS-CoV-2 with an EC50 of 18.6 nM. | ||
| M14500 | Osoresnontrine | PDE |
| BI-409306 | ||
| Osoresnontrine (BI-409306) is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 µM), PDE1C (IC50, 1.0 µM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all > 10 μM); Osoresnontrine can be used in the research of memory enhancement in CNS disorders. | ||
| M14676 | CSN5i-3 | Others |
| CSN5i-3 is a potent, selective and orally available inhibitor of CSN5/Jab1, and inhibits CSN-catalysed Cul1 deneddylation with an IC50 value of 5.8 nM. | ||
| M20690 | FT113 | FAS |
| FT113 is a potent inhibitor of fatty acid synthase(FASN) with ic50 of 213 nM. | ||
| M21426 | BRD-K98645985 | HIV Protease |
| BRD-K98645985 is a mammalian SWI/SNF transcriptional repressor inhibitor with an EC50 of ~2.37 µM. BRD-K98645985 binds ARID1A-specific BAF complex, prevents nucleosome localization, effectively reverses HIV-1 latency, and has no T-cell toxicity. | ||
| M21652 | SN-001 | STING |
| SN001 | ||
| SN-001 is a STING inhibitor with an IC50 of 3.82 μM. SN-001 targets the cyclic dinucleotide binding pocket of human STING. | ||
| M25090 | Grisnilimab setaritox | Others |
| WT1-RTA | ||
| Grisnilimab setaritox (WT1-RTA), is an antihuman T cell antibody (anti-CD7) conjugating with ricin A chain (RTA). RTA is a 30-kDa peptide capable of rapidly in activating ribosomal 60S subunits. Grisnilimab setaritox is cytotoxic to CEM (T-lymphoblastic leukemia) cells in vitro with an ID50 of 53 pM. Grisnilimab setaritox also improves leukemic meningitis model in rhesus monkeys. | ||
| M25407 | SN52 | NF-κB |
| SN-52 | ||
| SN52 is a novel potent, competitive, and cell-permeable inhibitor of nuclear factor-kappaB (NF-κB). SN52 is a variant of the SN50 peptide and inhibits the nuclear translocation of p52-RelB heterodimers. SN52 has a strong radiosensitization effect on prostate cancer cells. | ||
| M25471 | IPI-9119 | FAS |
| IPI-9119 is an orally active, selective and irreversible Fatty Acid Synthase (FASN) inhibitor, with an IC50 of 0.3 nM. | ||
| M27738 | SNT-207707 | Melanocortin Receptor |
| SNT-207707 is a selective, potent and orally active melanocortin MC-4 receptor antagonist with an IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor. | ||
| M27755 | SNX-0723 | HSP |
| SNX-0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity. SNX-0723 shows high binding affinity for HsHsp90 and PfHsp90 with Kis of 4.4 and 47 nM, respectively. SNX-0723 inhibits liver-stage P. berghei ANKA parasites with the EC50 of 3.3 μM. | ||
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
