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SC75741 is a broad and potent INHIBITOR of NF-κB with an IC50 of 200 nM against P65. SC75741 blocks replication of influenza viruses. SC75741 leads to decreased expression of cytokines, chemokines, and pro-apoptotic factors by impairing DNA binding of NF-κB subunit P65. Inhibit caspase activation and block caspase-mediated nuclear output of viralribonucleoproteins.
BMC Biol. 2021 May 20;19(1):108.
Very long intergenic non-coding (vlinc) RNAs directly regulate multiple genes in cis and trans
SC75741 purchased from AbMole
| Molecular Weight | 565.67 |
| Formula | C29H23N7O2S2 |
| CAS Number | 913822-46-5 |
| Solubility (25°C) | DMSO 45 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Leban J,et.al. Bioorg Med Chem Lett. A novel class of potent NF-kappaB signaling inhibitors.
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Products are for research use only. Not for human use. We do not sell to patients.
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