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Berbamine

Cat. No. M4756
Berbamine Structure
Size Price Availability Quantity
5mg USD 55  USD55 In stock
10mg USD 87  USD87 In stock
20mg USD 150  USD150 In stock
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Quality Control & Documentation
Biological Activity

Berbamine is a natural compound extracted from the traditional Chinese medicine Bovine, which has anti-tumor, immunomodulatory and cardiovascular effects. Berbamine is a calcium channel blocker.

Chemical Information
Molecular Weight 608.72
Formula C37H40N2O6
CAS Number 478-61-5
Form Solid
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Bin-Bin Yu, et al. Effect of berbamine on invasion and metastasis of human liver cancer SMMC-7721 cells and its possible mechanism

[2] Yu Jin Kim, et al. Antiangiogenic and antitumor potential of berbamine, a natural CaMKIIγ inhibitor, against glioblastoma

[3] Lihong Huang, et al. Berbamine inhibits SARS-CoV-2 infection by compromising TRPMLs-mediated endolysosomal trafficking of ACE2

[4] Chenglin Han, et al. Berbamine Suppresses the Progression of Bladder Cancer by Modulating the ROS/NF- κ B Axis

[5] Alexandria M Hudson, et al. Berbamine Analogs Exhibit Differential Protective Effects From Aminoglycoside-Induced Hair Cell Death

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