Cat.No. | Name | Information |
---|---|---|
M4005 | Pyrrolidinedithiocarbamate ammonium (PDTC) | Pyrrolidinedithiocarbamate ammonium (PDTC) is a selective nuclear factor-κB (NF-κB) inhibitor. |
M5580 | Dimethyl Fumarate | Dimethyl Fumarate (DMF) is an orally active Monomethyl fumarate (MMF) precursor compound that is also an Nrf2 pathway activator and inhibits NF-κB. In addition, Dimethyl Fumarate also inhibits GAPDH and can be used in studies related to multiple sclerosis (MS) and psoriasis. |
M4940 | SC75741 | SC75741 is a broad and potent INHIBITOR of NF-κB with an IC50 of 200 nM against P65. SC75741 blocks replication of influenza viruses. SC75741 leads to decreased expression of cytokines, chemokines, and pro-apoptotic factors by impairing DNA binding of NF-κB subunit P65. Inhibit caspase activation and block caspase-mediated nuclear output of viralribonucleoproteins. |
M3985 | Triptolide | Triptolide is a structurally unique diterpene triepoxide isolated from a traditional Chinese medicinal plant with anti-inflammatory, immunosuppressive, contraceptive and antitumor activities. |
M2298 | QNZ | QNZ is an inhibitor of NF-κB activation with IC50 of 11 nM. |
M7490 | Withaferin A | Withaferin A is a steroidal ester isolated from nightfruit, which can inhibit the activity of NF-kB, target vimentin, and has anti-inflammatory, anti-tumor and other effects. |
M2786 | JSH-23 | Jsh-23 is a NF-κB inhibitor, inhibited NF-κB transcriptional activity in lipopolysaccharid-stimulated macrophages RAW 264.7 with IC50 of 7.1 μM. Jsh-23 inhibited the nuclear translocation of NF-κB P65 without affecting the degradation of IκBα. |
M6179 | Diethylmaleate | Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB. |
M9456 | Berbamine dihydrochloride | Berbamine dihydrochloride is a novel inhibitor of NF-κB, inhibits growth and induces apoptosis in human myeloma cells. |
M8984 | Denosumab | Denosumab is designed to target RANKL (RANK ligand), a protein that acts as the primary signal to promote bone removal/resorption. |
M8600 | Urolithin B | Urolithin B is a natural product with antiproliferative and antioxidant activity. |
M8436 | Ethacrynic acid | Ethacrynic acid is a non-sulfa ring diuretic used to study hypertension and swelling caused by congestive heart failure, among other conditions. |
M7872 | Kojic acid | Tyrosinase inhibitor. |
M7752 | Sodium diethyldithiocarbamate trihydrate | Sodium diethyldithiocarbamate trihydrate is a chelating agent, generally used in mobilizing toxic metals from the human tissues and experimental animals. Sodium diethyldithiocarbamate trihydrate inhibits induction of macrophage nitric oxide synthase. |
M7633 | Bicyclol | Dicyclol is an anti-hepatitis compound used in studies of chronic hepatitis B and C in China. |
M7588 | N-acetylcysteine amide | N-Acetylcysteine amide is a thiol antioxidant and neuroprotective agent that crosses cell membranes and the blood-brain barrier, has anti-inflammatory activity, and is able to modulate NF-κB activation, HIF-1α and ROS. |
M6179 | Diethylmaleate | Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB. |
M5371 | 5-Aminosalicylic acid | 5-aminosalicylic acid (Mesalamine) is a specific PPARγ agonist that also inhibits P21-activated kinase 1 (PAK1) and NF-κB. |
M4786 | Aristolochic acid A | Aristolochic acid A (Aristolochic acid I; TR 1736) is the principal component of the plant extract Aristolochic Acids, found in Aristolochia and Asarum herbs. Aristolochic acid A significantly decreased activator protein 1 (AP-1) and NF-κB activity. Aristolochic acid A reduces the expression of bladder cancer-associated BLCAP gene in human cells. |
M4756 | Berbamine | Berbamine is a natural compound extracted from the traditional Chinese medicine Bovine, which has anti-tumor, immunomodulatory and cardiovascular effects. Berbamine is a calcium channel blocker. |
M4721 | Engeletin | Engeletin is a flavanonol glycoside isolated from Smilax glabra Roxb., it inhibits NF-κB signaling-pathway activation, and possesses anti-inflammatory, analgesic, diuresis, detumescence, and antibiosis effects. |
M4716 | Sauchinone | Sauchinone is a diastereoisomer lignan obtained from Saururus chinensis. Sauchinone inhibited LPS induced expression of iNOS, TNF-α and COX-2 by inhibiting phosphorylation of I-κBα and nuclear translocation of P65. Sauchinone has anti-inflammatory and antioxidant activities. |
M4685 | Obtusifolin | Obtusifolin, a new coumarin from roots of Haplophyllum obtusifolium, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway. |
M4680 | Rubimaillin | Mollugin is Rubia Cordifolia L. Is a major bioactive ingredient in the. Mollugin has anticancer effects by inhibiting NF-κB activation induced by TNF-α. Mollugin can enhance the osteogenic effect of BMP-2 through the P38-Smad signaling pathway. |
M4608 | Swertiamarin | Swertiamarin |
M4591 | Sodium-Aescinate | Sodium Aescinate is a triterpenoid saponin from Aesculus hippocastanum seeds with anti-inflammatory and antioxidant activities. Sodium aescinate inhibits liver cancer growth by targeting the CARMA3/NF-κB pathway. |
M4550 | Maslinic-acid | Maslinic-acid (MA) is a natural triterpenoid with a wide range of biological activities, such as anti-tumor, anti-diabetes, antioxidant, heart-protective, neuroprotective, anti-parasitic and growth stimulating, Maslinic acid inhibited THE DNA binding activity of NF-κB P65 and eliminated the PHOSPHORylation of IκB-α. |
M4533 | Dauricine | Dauricine is a diphenylisoquinoline alkaloid isolated from Asiatic Moonseed Rhizome and has anti-inflammatory activity. Dauricine inhibited proliferation, invasion and apoptosis of colon cancer cells in a dose-dependent manner by inhibiting NF-κB activation. |
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