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NF-κB Nuclear factor kappa-light-chain-enhancer of activated B cells

Cat.No.  Name Information
M4005 Pyrrolidinedithiocarbamate ammonium (PDTC) Pyrrolidinedithiocarbamate ammonium (PDTC) is a selective nuclear factor-κB (NF-κB) inhibitor.
M5580 Dimethyl Fumarate Dimethyl Fumarate (DMF) is an orally active Monomethyl fumarate (MMF) precursor compound that is also an Nrf2 pathway activator and inhibits NF-κB. In addition, Dimethyl Fumarate also inhibits GAPDH and can be used in studies related to multiple sclerosis (MS) and psoriasis.
M4940 SC75741 SC75741 is a broad and potent INHIBITOR of NF-κB with an IC50 of 200 nM against P65. SC75741 blocks replication of influenza viruses. SC75741 leads to decreased expression of cytokines, chemokines, and pro-apoptotic factors by impairing DNA binding of NF-κB subunit P65. Inhibit caspase activation and block caspase-mediated nuclear output of viralribonucleoproteins.
M3985 Triptolide Triptolide is a structurally unique diterpene triepoxide isolated from a traditional Chinese medicinal plant with anti-inflammatory, immunosuppressive, contraceptive and antitumor activities.
M2298 QNZ QNZ is an inhibitor of NF-κB activation with IC50 of 11 nM.
M7490 Withaferin A Withaferin A is a steroidal ester isolated from nightfruit, which can inhibit the activity of NF-kB, target vimentin, and has anti-inflammatory, anti-tumor and other effects.
M2786 JSH-23 Jsh-23 is a NF-κB inhibitor, inhibited NF-κB transcriptional activity in lipopolysaccharid-stimulated macrophages RAW 264.7 with IC50 of 7.1 μM. Jsh-23 inhibited the nuclear translocation of NF-κB P65 without affecting the degradation of IκBα.
M6179 Diethylmaleate Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB.
M9456 Berbamine dihydrochloride Berbamine dihydrochloride is a novel inhibitor of NF-κB, inhibits growth and induces apoptosis in human myeloma cells.
M8984 Denosumab Denosumab is designed to target RANKL (RANK ligand), a protein that acts as the primary signal to promote bone removal/resorption.
M8600 Urolithin B Urolithin B is a natural product with antiproliferative and antioxidant activity.
M8436 Ethacrynic acid Ethacrynic acid is a non-sulfa ring diuretic used to study hypertension and swelling caused by congestive heart failure, among other conditions.
M7872 Kojic acid Tyrosinase inhibitor.
M7752 Sodium diethyldithiocarbamate trihydrate Sodium diethyldithiocarbamate trihydrate is a chelating agent, generally used in mobilizing toxic metals from the human tissues and experimental animals. Sodium diethyldithiocarbamate trihydrate inhibits induction of macrophage nitric oxide synthase.
M7633 Bicyclol Dicyclol is an anti-hepatitis compound used in studies of chronic hepatitis B and C in China.
M7588 N-acetylcysteine amide N-Acetylcysteine amide is a thiol antioxidant and neuroprotective agent that crosses cell membranes and the blood-brain barrier, has anti-inflammatory activity, and is able to modulate NF-κB activation, HIF-1α and ROS.
M6179 Diethylmaleate Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB.
M5371 5-Aminosalicylic acid 5-aminosalicylic acid (Mesalamine) is a specific PPARγ agonist that also inhibits P21-activated kinase 1 (PAK1) and NF-κB.
M4786 Aristolochic acid A Aristolochic acid A (Aristolochic acid I; TR 1736) is the principal component of the plant extract Aristolochic Acids, found in Aristolochia and Asarum herbs. Aristolochic acid A significantly decreased activator protein 1 (AP-1) and NF-κB activity. Aristolochic acid A reduces the expression of bladder cancer-associated BLCAP gene in human cells.
M4756 Berbamine Berbamine is a natural compound extracted from the traditional Chinese medicine Bovine, which has anti-tumor, immunomodulatory and cardiovascular effects. Berbamine is a calcium channel blocker.
M4721 Engeletin Engeletin is a flavanonol glycoside isolated from Smilax glabra Roxb., it inhibits NF-κB signaling-pathway activation, and possesses anti-inflammatory, analgesic, diuresis, detumescence, and antibiosis effects.
M4716 Sauchinone Sauchinone is a diastereoisomer lignan obtained from Saururus chinensis. Sauchinone inhibited LPS induced expression of iNOS, TNF-α and COX-2 by inhibiting phosphorylation of I-κBα and nuclear translocation of P65. Sauchinone has anti-inflammatory and antioxidant activities.
M4685 Obtusifolin Obtusifolin, a new coumarin from roots of Haplophyllum obtusifolium, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway.
M4680 Rubimaillin Mollugin is Rubia Cordifolia L. Is a major bioactive ingredient in the. Mollugin has anticancer effects by inhibiting NF-κB activation induced by TNF-α. Mollugin can enhance the osteogenic effect of BMP-2 through the P38-Smad signaling pathway.
M4608 Swertiamarin Swertiamarin
M4591 Sodium-Aescinate Sodium Aescinate is a triterpenoid saponin from Aesculus hippocastanum seeds with anti-inflammatory and antioxidant activities. Sodium aescinate inhibits liver cancer growth by targeting the CARMA3/NF-κB pathway.
M4550 Maslinic-acid Maslinic-acid (MA) is a natural triterpenoid with a wide range of biological activities, such as anti-tumor, anti-diabetes, antioxidant, heart-protective, neuroprotective, anti-parasitic and growth stimulating, Maslinic acid inhibited THE DNA binding activity of NF-κB P65 and eliminated the PHOSPHORylation of IκB-α.
M4533 Dauricine Dauricine is a diphenylisoquinoline alkaloid isolated from Asiatic Moonseed Rhizome and has anti-inflammatory activity. Dauricine inhibited proliferation, invasion and apoptosis of colon cancer cells in a dose-dependent manner by inhibiting NF-κB activation.




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