| Cat.No. | Name | Information |
|---|---|---|
| M4005 | PDTC | Pyrrolidinedithiocarbamate ammonium (PDTC) is a selective and blood-brain barrier (BBB) permeable nuclear factor-κB (NF-κB) inhibitor. |
| M4940 | SC75741 | SC75741 is a broad and potent INHIBITOR of NF-κB with an IC50 of 200 nM against P65. SC75741 blocks replication of influenza viruses. SC75741 leads to decreased expression of cytokines, chemokines, and pro-apoptotic factors by impairing DNA binding of NF-κB subunit P65. Inhibit caspase activation and block caspase-mediated nuclear output of viralribonucleoproteins. |
| M3985 | Triptolide | Triptolide is a structurally unique diterpene triepoxide isolated from a traditional Chinese medicinal plant with anti-inflammatory, immunosuppressive, contraceptive and antitumor activities. |
| M9331 | Royal Jelly acid | Royal Jelly acid (10-hydroxy-2-decenoic acid) is the principal lipid component in royal jelly which is the food for queen and larvae honeybees. |
| M2298 | QNZ | QNZ is an inhibitor of NF-κB activation with IC50 of 11 nM. |
| M7490 | Withaferin A | Withaferin A is a steroidal ester isolated from nightfruit, which can inhibit the activity of NF-kB, target vimentin, and has anti-inflammatory, anti-tumor and other effects. |
| M2786 | JSH-23 | Jsh-23 is a NF-κB inhibitor, inhibited NF-κB transcriptional activity in lipopolysaccharid-stimulated macrophages RAW 264.7 with IC50 of 7.1 μM. Jsh-23 inhibited the nuclear translocation of NF-κB P65 without affecting the degradation of IκBα. |
| M6179 | Diethylmaleate | Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB. |
| M5371 | 5-Aminosalicylic acid | 5-aminosalicylic acid (Mesalamine) is a specific PPARγ agonist that also inhibits P21-activated kinase 1 (PAK1) and NF-κB. |
| M7588 | N-acetylcysteine amide | N-Acetylcysteine amide is a thiol antioxidant and neuroprotective agent that crosses cell membranes and the blood-brain barrier, has anti-inflammatory activity, and is able to modulate NF-κB activation, HIF-1α and ROS. |
| M14603 | Indole-3-carbinol | Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1). |
| M14600 | DCZ0415 | DCZ0415, a potent TRIP13 inhibitor, impairs nonhomologous end joining repair and inhibits NF-κB activity. DCZ0415 induces anti-myeloma activity in vitro, in vivo, and in primary cells derived from drug-resistant myeloma patients. |
| M14599 | Asatone | Asatone is an active component isolated from Radix et Rhizoma Asari, with anti-inflammatory effect via activation of NF-κB and donwn regulation of p-MAPK (ERK, JNK and p38) pathways. |
| M14598 | Inulicin | Inulicin (1-O-Acetylbritannilactone) is an active compound that inhibits VEGF-mediated activation of Src and FAK. |
| M14597 | 14-Deoxy-11,12-didehydroandrographolide | 14-Deoxy-11,12-didehydroandrographolide is an analogue of Andrographolide. 14-Deoxy-11,12-didehydroandrographolide inhibits NF-κB activation. |
| M13449 | Ac2-26 TFA | Ac2-26 TFA, an active N-terminal peptide of adiponectin A1 (AnxA1), alleviates acute lung injury induced by ischemia-reperfusion. Ac2-26 also decreased AnxA1 protein expression and inhibited the activation of NF-κB and MAPK pathways in damaged lung tissue. Sequence Shortening: Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-GIn-Ala-Trp-Phe-lle-Glu-Asn-Glu-Glu-GIn-Glu-Tyr-Val-GIn-Thr-Val-Lys |
| M11094 | Poricoic acid A | Poricoic acid A is derived from Polya cocos and has anti-tumor activity. Poricoic acid A enhances melatonin inhibition of AKI-to-CKD by modulating the Gas6/AxlNFκB/Nrf2 axis. |
| M10982 | α-Lipoic Acid | α-Lipoic Acid is an antioxidant that is an important cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum stress (ER)-mediated apoptosis of liver cancer cells. |
| M10653 | Dehydroevodiamine | Dehydroevodiamine has an antiarrhythmic effect in guinea-pig ventricular myocytes. Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells. |
| M10545 | SN50 | SN50 is a cell permeable inhibitor of NF-κB translocation. |
| M9949 | NIK SMI1 | NIK SMI1 is a highly selective and potent NF-κB-inducing kinase (NIK) inhibitor. |
| M9825 | Helenalin | Helenalin is an anti-inflammatory sesquiterpene lactone, it selectively inhibits transcription factor NF-κB by directly targeting p65. Helenalin effectively inhibits C/EBPβ at least 10 times higher than that for NF-κB (EC50 values were determined between 0.1 and 0.4 μM for C/EBPβ). |
| M9645 | Licochalcone D | Licochalcone D is a potent inhibitor of NF-kappaB (NF-κB) p65 with antioxidant, anti-inflammatory, anti-cancer properties. |
| M9456 | Berbamine dihydrochloride | Berbamine dihydrochloride is a novel inhibitor of NF-κB, inhibits growth and induces apoptosis in human myeloma cells. |
| M8984 | Denosumab | Denosumab is designed to target RANKL (RANK ligand), a protein that acts as the primary signal to promote bone removal/resorption. |
| M8600 | Urolithin B | Urolithin B is a natural product with antiproliferative and antioxidant activity. |
| M8436 | Ethacrynic acid | Ethacrynic acid is a non-sulfa ring diuretic used to study hypertension and swelling caused by congestive heart failure, among other conditions. |
| M7752 | Sodium diethyldithiocarbamate trihydrate | Sodium diethyldithiocarbamate trihydrate is a chelating agent, generally used in mobilizing toxic metals from the human tissues and experimental animals. Sodium diethyldithiocarbamate trihydrate inhibits induction of macrophage nitric oxide synthase. |
| M7633 | Bicyclol | Bicyclol regulates the expression of heat shock proteins and plays an anti-apoptosis role in hepatocytes. Bicyclol reduces the activation of NF-κB and the levels of inflammatory factors in hepatocytes infected with hepatitis C virus (HCV) by inhibiting the activation of the ROS-MAPK-NF-κB pathway, and prevents ferroptosis in acute liver injury. Dicyclol is an anti-hepatitis compound used in studies of chronic hepatitis B and C in China. |
| M4786 | Aristolochic acid A | Aristolochic acid A (Aristolochic acid I; TR 1736) is the principal component of the plant extract Aristolochic Acids, found in Aristolochia and Asarum herbs. Aristolochic acid A significantly decreased activator protein 1 (AP-1) and NF-κB activity. Aristolochic acid A reduces the expression of bladder cancer-associated BLCAP gene in human cells. |
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