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Sinomenine, an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-κB activation. Sinomenine also is an activator of μ-opioid receptor.
Sinomenine (10 to 40 mg/kg) dose-dependently increases the paw withdrawal threshold.
| Molecular Weight | 329.39 |
| Formula | C19H23NO4 |
| CAS Number | 115-53-7 |
| Solubility (25°C) | DMSO 50 mg/mL 1M HCl: 25 mg/mL (ultrasonic and adjust pH to 1 with HCl) |
| Storage | 2-8°C, protect from light |
[2] Wei Jiang, et al. Analgesic Mechanism of Sinomenine against Chronic Pain
[3] Le-Nyu Gao, et al. Mechanism Underlying Antitumor Effects of Sinomenine
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