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Tomatidine

Cat. No. M14611
Tomatidine Structure
Size Price Availability Quantity
20mg USD 180  USD180 In stock
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Quality Control & Documentation
Biological Activity

Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. Tomatidine activates autophagy either in mammal cells or C elegans.

Chemical Information
Molecular Weight 415.65
CAS Number 77-59-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Berit Troost-Kind, et al. Tomatidine reduces Chikungunya virus progeny release by controlling viral protein expression

[2] Wen-Chung Huang, et al. Tomatidine Improves Pulmonary Inflammation in Mice with Acute Lung Injury

[3] Yu-Ting Wang, et al. Tomatidine provides mitophagy-independent neuroprotection after ischemic injury

[4] Shu-Ju Wu, et al. Tomatidine ameliorates obesity-induced nonalcoholic fatty liver disease in mice

[5] Evandro F Fang, et al. Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway

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Keywords: Tomatidine supplier, NF-κB, inhibitors, activators


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