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Micheliolide

Cat. No. M14605
Micheliolide Structure
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Biological Activity

Micheliolide could effectively attenuate the high glucose-stimulated activation of NF-κB, the degradation of IκBα, and the expression of MCP-1, TGF-β1 and FN in rat mesangial cells (MCs).

Chemical Information
Molecular Weight 248.32
CAS Number 68370-47-8
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Peizhong Kong, et al. Micheliolide Enhances Radiosensitivities of p53-Deficient Non-Small-Cell Lung Cancer via Promoting HIF-1α Degradation

[2] Fenfen Peng, et al. Correction: Micheliolide ameliorates renal fibrosis by suppressing the Mtdh/BMP/MAPK pathway

[3] Fenfen Peng, et al. Micheliolide ameliorates renal fibrosis by suppressing the Mtdh/BMP/MAPK pathway

[4] Narsimha Reddy Penthala, et al. (E)-13-(2-Bromo-phen-yl)micheliolide

[5] Shobanbabu Bommagani, et al. 13-(N,N-Di-methyl-amino)-micheliolide 0.08-hydrate

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Keywords: Micheliolide supplier, NF-κB, inhibitors, activators


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