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Cat. No. M10653
Dehydroevodiamine Structure
Size Price Availability Quantity
5mg USD 80  USD80 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Dehydroevodiamine has an antiarrhythmic effect in guinea-pig ventricular myocytes. Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 301.35
Formula C19H15N3O
CAS Number 67909-49-3
Purity >99%
Solubility DMSO
Storage 2-8°C, dry, sealed

[1] Hee Dong Jeon, et al. Phytomedicine. Dehydroevodiamine inhibits lung metastasis by suppressing survival and metastatic abilities of colorectal cancer cells

[2] Yufang Dai, et al. Bioengineered. Dehydroevodiamine suppresses inflammatory responses in adjuvant-induced arthritis rats and human fibroblast-like synoviocytes

[3] Ying Wei, et al. Phytomedicine. Dehydroevodiamine ameliorates indomethacin-induced gastric injury via inhibition of ERK and p38 signaling pathway

[4] Jian-Xia Wen, et al. Phytomedicine. Therapeutic effects and potential mechanism of dehydroevodiamine on N-methyl-N'-nitro-N-nitrosoguanidine-induced chronic atrophic gastritis

[5] H H Wang, et al. Eur J Pharmacol. Dehydroevodiamine attenuates beta-amyloid peptide-induced amnesia in mice

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Abmole Inhibitor Catalog 2017

Keywords: Dehydroevodiamine supplier, NF-κB, inhibitors

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