Pyrrolidinedithiocarbamate ammonium (PDTC) can enhance the cell apoptosis induced by TNF-α, which may be associated with the blocking of TNF-α-activated NF-κB signaling pathway by PDTC, the down-regulation of survivin expression, and up-regulation of caspase-3 expression.in NMSC PDTC acts as pro-oxidant and enhances IR-induced cell cytotoxicity by increasing H(2)O(2)formation and thiol oxidation.PDTC and MG132, inhibitors of NF-kappaB, block ET-induced vasodilation in isolated rat skeletal muscle arterioles.PDTC has effects at both the level of the aortic segment as well as the resistance arteriole.PDTC prevents induction of nitric oxide synthase (NOS) by inhibiting translation of NOS mRNA.PDTC induces apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells.
Bioengineered. 2022 May;13(5):13689-13702.
Toll-like receptor 9 (TLR9) gene deletion-mediated fracture healing in type II diabetic osteoporosis associates with inhibition of the nuclear factor-kappa B (NF-κB)
Pyrrolidinedithiocarbamate ammonium (PDTC) purchased from AbMole
J Extracell Vesicles. 2022 May;11(5):e12218.
CD73 in small extracellular vesicles derived from HNSCC defines tumour‐associated immunosuppression mediated by macrophages in the microenvironment
Pyrrolidinedithiocarbamate ammonium (PDTC) purchased from AbMole
Int J Chron Obstruct Pulmon Dis. 2021 Jun 4;16:1661-1675.
Histone Deacetylase 2 Suppresses Skeletal Muscle Atrophy and Senescence via NF-κB Signaling Pathway in Cigarette Smoke-Induced Mice with Emphysema
Pyrrolidinedithiocarbamate ammonium (PDTC) purchased from AbMole
Oncol Rep. 2020 Aug;44(2):577-588.
TNF‑α promotes the malignant transformation of intestinal stem cells through the NF‑κB and Wnt/β‑catenin signaling pathways
Pyrrolidinedithiocarbamate ammonium (PDTC) purchased from AbMole
J Exp Clin Cancer Res. 2020 May 24;39(1):93.
TFEB-NF-κB Inflammatory Signaling Axis: A Novel Therapeutic Pathway of Dihydrotanshinone I in Doxorubicin-Induced Cardiotoxicity
Pyrrolidinedithiocarbamate ammonium (PDTC) purchased from AbMole
Cell Mol Neurobiol. 2019 Mar;39(2):301-319.
Myosin IIA Regulated Tight Junction in Oxygen Glucose-Deprived Brain Endothelial Cells Via Activation of TLR4/PI3K/Akt/JNK1/2/14-3-3ε/NF-κB/MMP9 Signal Transduction Pathway.
Pyrrolidinedithiocarbamate ammonium (PDTC) purchased from AbMole
Vet Microbiol. 2018 Sep;223:9-20.
Dendritic cell-targeted recombinantLactobacilli induce DC activation and elicit specific immune responses against G57 genotype of avian H9N2 influenza virus infection.
Pyrrolidinedithiocarbamate ammonium (PDTC) purchased from AbMole
Arthritis Research & Therapy. 2018 Oct 4;20:225.
E2F2 directly regulates the STAT1 and PI3K/AKT/NF-κB pathways to exacerbate the inflammatory phenotype in rheumatoid arthritis synovial fibroblasts and mouse embryonic fibroblasts.
Pyrrolidinedithiocarbamate ammonium (PDTC) purchased from AbMole
J Infect Dis. 2018 May 8.
Tumor Necrosis Factor-α Is Required for Mast Cell-Mediated Host Immunity Against Cutaneous Staphylococcus aureus Infection.
Pyrrolidinedithiocarbamate ammonium (PDTC) purchased from AbMole
Sci Rep. 2017 Dec 15;7(1):17677.
Host species adaptation of TLR5 signalling and flagellin recognition
Pyrrolidinedithiocarbamate ammonium (PDTC) purchased from AbMole
Vet Microbiol. 2017 May;203:158-166.
Newcastle disease virus-like particles induce DC maturation through TLR4/NF-κB pathway and facilitate DC migration by CCR7-CCL19/CCL21 axis.
Pyrrolidinedithiocarbamate ammonium (PDTC) purchased from AbMole
Molecular Weight | 164.29 |
Formula | C5H9NS2·NH3 |
CAS Number | 5108-96-3 |
Solubility (25°C) | Water 30 mg/mL DMSO 30 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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