| Cat.No. | Name | Information |
|---|---|---|
| M4005 | PDTC | Pyrrolidinedithiocarbamate ammonium (PDTC) is a selective and blood-brain barrier (BBB) permeable nuclear factor-κB (NF-κB) inhibitor. |
| M4940 | SC75741 | SC75741 is a broad and potent INHIBITOR of NF-κB with an IC50 of 200 nM against P65. SC75741 blocks replication of influenza viruses. SC75741 leads to decreased expression of cytokines, chemokines, and pro-apoptotic factors by impairing DNA binding of NF-κB subunit P65. Inhibit caspase activation and block caspase-mediated nuclear output of viralribonucleoproteins. |
| M3985 | Triptolide | Triptolide is a structurally unique diterpene triepoxide isolated from a traditional Chinese medicinal plant with anti-inflammatory, immunosuppressive, contraceptive and antitumor activities. |
| M9331 | Royal Jelly acid | Royal Jelly acid (10-hydroxy-2-decenoic acid) is the principal lipid component in royal jelly which is the food for queen and larvae honeybees. |
| M2298 | QNZ | QNZ is an inhibitor of NF-κB activation with IC50 of 11 nM. |
| M7490 | Withaferin A | Withaferin A is a steroidal ester isolated from nightfruit, which can inhibit the activity of NF-kB, target vimentin, and has anti-inflammatory, anti-tumor and other effects. |
| M2786 | JSH-23 | Jsh-23 is a NF-κB inhibitor, inhibited NF-κB transcriptional activity in lipopolysaccharid-stimulated macrophages RAW 264.7 with IC50 of 7.1 μM. Jsh-23 inhibited the nuclear translocation of NF-κB P65 without affecting the degradation of IκBα. |
| M6179 | Diethylmaleate | Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB. |
| M5371 | 5-Aminosalicylic acid | 5-aminosalicylic acid (Mesalamine) is a specific PPARγ agonist that also inhibits P21-activated kinase 1 (PAK1) and NF-κB. |
| M7588 | N-acetylcysteine amide | N-Acetylcysteine amide is a thiol antioxidant and neuroprotective agent that crosses cell membranes and the blood-brain barrier, has anti-inflammatory activity, and is able to modulate NF-κB activation, HIF-1α and ROS. |
| M4278 | Rhynchophylline | Rhyncholphylline is a kind of alkaloid compound isolated from Uncaria. It has high biological activity and has been widely used in anti-inflammatory and neuroprotective studies. |
| M4276 | Tyrosol | Tyrosol is a derivative of phenyl ethanol. Tyrosol attenuates pro-inflammatory cytokines from astrocytes and decreases NF-κB activation. It has antioxidant and anti-inflammatory effects. |
| M4249 | Schisandrol B | Schisandrol B is a major active constituent of Schisandra sphenanthera with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities. |
| M4230 | Armepavine | Armepavine is an active compound from Nelumbo Nucifera, which not only has anti-inflammatory effect on human peripheral blood monocytes, but also has immunosuppressive effect on T lymphocytes and lupus nephritis mice. Armepavine inhibits TNF-α - induced MAPK and NF-κB signaling cascade. |
| M4228 | Neferine | Neferine is a bisbenzylisoquinoline alkaloid extracted from Plumbago officinalis, which reduces lipid accumulation and promotes β-oxidation through activation of the AMPK pathway in hepatocytes, and possesses anti-inflammatory, antioxidant, and antipulmonary fibrosis activities. In addition, Neferine potently inhibits NF-κB activation.The affinity Kd value of Neferine for ABCB1 is 0.659 μM.It can be used in studies related to non-alcoholic steatohepatitis (NASH). |
| M4187 | Senegenin | Tenuigenin is the main active ingredient isolated from the roots of Polygala tenuifolia. Tenuigenin prevents staphylococcus aureus-induced pneumonia by inhibiting NF-κB activation. |
| M4179 | Neochlorogenic-acid | Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid can inhibit the production of TNF-α and IL-1β. Neochlorogenic acid inhibited the expression of iNOS and COX-2 proteins. Neochlorogenic acid also inhibited the activation of phosphorylated NF-κB P65 and P38 MAPK. |
| M4126 | Zingerone | Zingerone (Vanillylacetone) is a non-toxic methoxyphenol obtained from ginger. It has anti-inflammatory, anti-diabetes, anti-lipid allergy, anti-diarrhea, anti-spasticity and anti-tumor activities. Zingerone reduces oxidative stress and inflammation and down-regulates NF-κB signaling. Zingerone acts as an anti-mitotic agent and inhibits the growth of neuroblastoma. |
| M4092 | Ginsenoside-Rk1 | Ginsenoside Rk1 is a high-temperature processed extract of ginseng. Ginsenoside Rk1 has anti-inflammatory effects and inhibits Jak2/Stat3 signaling pathway and NF-κB activation. |
| M4091 | Ginsenoside-Rg6 | Ginsenoside Rg6 inhibited NF-κB transcriptional activity induced by TNF-α in HepG2 cells with IC50 of 29.34 μM. Ginsenoside Rg6 also induced apoptosis. |
| M4075 | Ginsenoside-Rd | Ginsenoside Rd inhibited NF-κB transcriptional activity induced by TNFα with IC50 of 12.05±0.82 μM. Ginsenoside Rd inhibited the expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside Rd inhibited CYP2D6, CYP1A2, CYP3A4 and CYP2C9 with IC50 of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM and 85.1±9.1 μM, respectively. |
| M4067 | Ginsenoside-Rg2 | Ginsenoside-Rg2 is one of the major active components of ginseng, acts as a NF-κB inhibitor. |
| M4066 | Ginsenoside-Rb3 | Ginsenoside Rb3 is derived from Panax Notoginseng. Ginsenoside Rb3 inhibited NF-κB transcriptional activity induced by TNFα in 293T cell lines with IC50 of 8.2 μM. Ginsenoside Rb3 also inhibited the induction of COX-2 and iNOS mRNA. |
| M4028 | Karacoline | Karacoline, a diterpenoid alkaloid found in Aconitum Kusnezoffii, reduces extracellular matrix degradation in intervertebral disc degeneration through the NF-κB signaling pathway. |
| M4025 | Aconine | Aconine inhibits NF-κB activation induced by the activator ligand of nuclear factor κB receptor. |
| M3963 | Bruceine A | Brucaine A (Brucea javanica A) is a natural bitter bitter compound, extracted from the dried fruit of Brucea javanica, which can act on dog scorch. |
| M3930 | Parthenolide | Parthenolide (PTL) is a sesquiterpene lactone isolated from feverfew and exhibits potent antitumor activity against various cancers. |
| M3461 | Sulindac | Sulindac (Clinoril) is a non-steroidal anti-inflammatory agent of the arylalkanoic acid class. |
| M3017 | Sodium 4-Aminosalicylate | Sodium 4-Aminosalicylate is an antibiotic used to treat tuberculosis via NF-κB inhibition and free radical scavenging. |
| M2844 | Methylthiouracil | Methylthiouracil is an anti-thyroid agent. Methylthiouracil inhibits TNF-α and IL-6 production and NF-κB and ERK1/2 activation. |
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