| Cat.No. | Name | Information |
|---|---|---|
| M4005 | Pyrrolidinedithiocarbamate ammonium (PDTC) | Pyrrolidinedithiocarbamate ammonium (PDTC) is a selective nuclear factor-κB (NF-κB) inhibitor. |
| M5580 | Dimethyl Fumarate | Dimethyl Fumarate (DMF) is an orally active Monomethyl fumarate (MMF) precursor compound that is also an Nrf2 pathway activator and inhibits NF-κB. In addition, Dimethyl Fumarate also inhibits GAPDH and can be used in studies related to multiple sclerosis (MS) and psoriasis. |
| M4940 | SC75741 | SC75741 is a broad and potent INHIBITOR of NF-κB with an IC50 of 200 nM against P65. SC75741 blocks replication of influenza viruses. SC75741 leads to decreased expression of cytokines, chemokines, and pro-apoptotic factors by impairing DNA binding of NF-κB subunit P65. Inhibit caspase activation and block caspase-mediated nuclear output of viralribonucleoproteins. |
| M3985 | Triptolide | Triptolide is a structurally unique diterpene triepoxide isolated from a traditional Chinese medicinal plant with anti-inflammatory, immunosuppressive, contraceptive and antitumor activities. |
| M2298 | QNZ | QNZ is an inhibitor of NF-κB activation with IC50 of 11 nM. |
| M7490 | Withaferin A | Withaferin A is a steroidal ester isolated from nightfruit, which can inhibit the activity of NF-kB, target vimentin, and has anti-inflammatory, anti-tumor and other effects. |
| M2786 | JSH-23 | Jsh-23 is a NF-κB inhibitor, inhibited NF-κB transcriptional activity in lipopolysaccharid-stimulated macrophages RAW 264.7 with IC50 of 7.1 μM. Jsh-23 inhibited the nuclear translocation of NF-κB P65 without affecting the degradation of IκBα. |
| M6179 | Diethylmaleate | Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB. |
| M4091 | Ginsenoside-Rg6 | Ginsenoside Rg6 inhibited NF-κB transcriptional activity induced by TNF-α in HepG2 cells with IC50 of 29.34 μM. Ginsenoside Rg6 also induced apoptosis. |
| M4075 | Ginsenoside-Rd | Ginsenoside Rd inhibited NF-κB transcriptional activity induced by TNFα with IC50 of 12.05±0.82 μM. Ginsenoside Rd inhibited the expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside Rd inhibited CYP2D6, CYP1A2, CYP3A4 and CYP2C9 with IC50 of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM and 85.1±9.1 μM, respectively. |
| M4067 | Ginsenoside-Rg2 | Ginsenoside-Rg2 is one of the major active components of ginseng, acts as a NF-κB inhibitor. |
| M4066 | Ginsenoside-Rb3 | Ginsenoside Rb3 is derived from Panax Notoginseng. Ginsenoside Rb3 inhibited NF-κB transcriptional activity induced by TNFα in 293T cell lines with IC50 of 8.2 μM. Ginsenoside Rb3 also inhibited the induction of COX-2 and iNOS mRNA. |
| M4028 | Karacoline | Karacoline, a diterpenoid alkaloid found in Aconitum Kusnezoffii, reduces extracellular matrix degradation in intervertebral disc degeneration through the NF-κB signaling pathway. |
| M4025 | Aconine | Aconine inhibits NF-κB activation induced by the activator ligand of nuclear factor κB receptor. |
| M3963 | Bruceine A | Brucaine A (Brucea javanica A) is a natural bitter bitter compound, extracted from the dried fruit of Brucea javanica, which can act on dog scorch. |
| M3930 | Parthenolide | Parthenolide (PTL) is a sesquiterpene lactone isolated from feverfew and exhibits potent antitumor activity against various cancers. |
| M3920 | Naringin dihydrochalcone | Naringin dihydrochalcone, sometimes abbreviated to naringin DC, is an artificial sweetener derived from naringin, a bitter compound found in citrus. |
| M3461 | Sulindac | Sulindac (Clinoril) is a non-steroidal anti-inflammatory agent of the arylalkanoic acid class. |
| M3161 | Betulinic acid | Betulinic acid is a natural pentacyclic triterpenoid compound, which is an inhibitor of eukaryotic cell topoisomerase I with IC50 value of 5 μM. It has anti-inflammatory, anti-malaria, anti-AIDS and anti-tumor activities. Betulinic acid(Betulinic acid) is also an agonist of 20S proteasome. EC50=5.5μmol/L, Betulinic acid can specifically enhance cT-L activity of 20S proteasome. |
| M3017 | Sodium 4-Aminosalicylate | Sodium 4-Aminosalicylate is an antibiotic used to treat tuberculosis via NF-κB inhibition and free radical scavenging. |
| M2844 | Methylthiouracil | Methylthiouracil is an anti-thyroid agent. Methylthiouracil inhibits TNF-α and IL-6 production and NF-κB and ERK1/2 activation. |
| M2501 | Cepharanthine | Cepharanthine is a biscoclaurine alkaloid inhibiting tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and suppressing cytokine production. |
| M2484 | Caffeic Acid Phenethyl Ester | Caffeic acid phenethyl ester is a potent and specific inhibitor of NF-κB activation, and also displays antioxidant, immunomodulatory and antiinflammatory activities. |
| M54521 | Narlumosbart | Narlumosbart is a human IgG4ҡ monoclonal antibody (mAb) that targets Receptor Activating Factor for Nuclear Factor κB Ligand (RANKL) and can be used in studies related to Giant Cell Tumor of Bone (GCTB). |
| M54279 | Ac2-26 | Ac2-26, an active N-terminal peptide of annexin A1 (AnxA1), attenuates ischemia-reperfusion-induced acute lung injury. |
| M52815 | Mitogen-activated protein kinase 1 | Mitogen-activated protein kinase 1 (MAPK1) can activate the downstream p38/NF-κB pathway. |
| M52370 | IKKγ NBD Inhibitory Peptide | IKKγ NBD Inhibitory Peptide is a highly specific inhibitor NF-κB inhibitor. |
| M52369 | Tripeptide-41 | Tripeptide-41(CG-Lipoxyn)isa bioactive peptide withreduce fat accumulationeffect and has been reported used as a cosmetic ingredient. |
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