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Parthenolide

Cat. No. M3930
Parthenolide Structure
Synonym:

(-)-Parthenolide

Size Price Availability Quantity
50mg USD 50  USD50 In stock
100mg USD 75  USD75 In stock
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Quality Control & Documentation
Biological Activity

Parthenolide inhibits the growth of the promastigote form of L. amazonensis (IC50 = 3.6 μg/ml). Parthenolide also induces apoptosis in cancer cells, at least in part by inhibiting NF-κB- and STAT-mediated anti-apoptotic gene transcription. Parthenolide has also been shown to block inflammation by inhibiting signaling through NF-κB. Inhibition of NF-κB by parthenolide can be achieved by direct binding of the pattern recognition receptor NOD2 by parthenolide. COX-2 inhibition is the mechanism by which parthenolide induces cell death in the cancer stem-like cells of nasopharyngeal carcinoma. In addition, parthenolide exhibited an inhibitory effect on nuclear factor-kappa B (NF-κB) nucler translocation by suppressing both the phosphorylation of IκB kinase complex and IκBα degradation.

Chemical Information
Molecular Weight 248.32
Formula C15H20O3
CAS Number 20554-84-1
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Liao K, et al. Theranostics. Parthenolide inhibits cancer stem-like side population of nasopharyngeal carcinoma cells via suppression of the NF-κB/COX-2 pathway.

[2] Lan B Biochem Biophys Res Commun. Parthenolide induces autophagy via the depletion of 4E-BP1.

[3] Al-Fatlawi AA, et al. Pharm Biol. Effect of parthenolide on growth and apoptosis regulatory genes of human cancer cell lines.

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Keywords: Parthenolide, (-)-Parthenolide supplier, NF-κB, inhibitors, activators


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