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Neferine is a bisbenzylisoquinoline alkaloid extracted from Plumbago officinalis, which reduces lipid accumulation and promotes β-oxidation through activation of the AMPK pathway in hepatocytes, and possesses anti-inflammatory, antioxidant, and antipulmonary fibrosis activities. In addition, Neferine potently inhibits NF-κB activation.The affinity Kd value of Neferine for ABCB1 is 0.659 μM.It can be used in studies related to non-alcoholic steatohepatitis (NASH).
| Molecular Weight | 624.77 |
| Formula | C38H44N2O6 |
| CAS Number | 2292-16-2 |
| Form | Solid |
| Solubility (25°C) | DMSO |
| Storage | 4°C |
[5] Shibu Marthandam Asokan, et al. Pharmacological benefits of neferine - A comprehensive review
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