Tyrosol is a derivative of phenyl ethanol. Tyrosol attenuates pro-inflammatory cytokines from astrocytes and decreases NF-κB activation. It has antioxidant and anti-inflammatory effects.
| Molecular Weight | 138.16 |
| Formula | C8H10O2 |
| CAS Number | 501-94-0 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage | 4°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Tuncer Kutlu, et al. Tyrosol retards induction of fibrosis in rats
[2] Jarrod Cohen, et al. Tyrosol-Derived Biodegradable Inks with Tunable Properties for 3D Printing
[3] Mark B Plotnikov, et al. Tyrosol as a Neuroprotector: Strong Effects of a "Weak" Antioxidant
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