| Cat.No. | Name | Information |
|---|---|---|
| M4005 | PDTC | Pyrrolidinedithiocarbamate ammonium (PDTC) is a selective and blood-brain barrier (BBB) permeable nuclear factor-κB (NF-κB) inhibitor. |
| M4940 | SC75741 | SC75741 is a broad and potent INHIBITOR of NF-κB with an IC50 of 200 nM against P65. SC75741 blocks replication of influenza viruses. SC75741 leads to decreased expression of cytokines, chemokines, and pro-apoptotic factors by impairing DNA binding of NF-κB subunit P65. Inhibit caspase activation and block caspase-mediated nuclear output of viralribonucleoproteins. |
| M3985 | Triptolide | Triptolide is a structurally unique diterpene triepoxide isolated from a traditional Chinese medicinal plant with anti-inflammatory, immunosuppressive, contraceptive and antitumor activities. |
| M9331 | Royal Jelly acid | Royal Jelly acid (10-hydroxy-2-decenoic acid) is the principal lipid component in royal jelly which is the food for queen and larvae honeybees. |
| M2298 | QNZ | QNZ is an inhibitor of NF-κB activation with IC50 of 11 nM. |
| M7490 | Withaferin A | Withaferin A is a steroidal ester isolated from nightfruit, which can inhibit the activity of NF-kB, target vimentin, and has anti-inflammatory, anti-tumor and other effects. |
| M2786 | JSH-23 | Jsh-23 is a NF-κB inhibitor, inhibited NF-κB transcriptional activity in lipopolysaccharid-stimulated macrophages RAW 264.7 with IC50 of 7.1 μM. Jsh-23 inhibited the nuclear translocation of NF-κB P65 without affecting the degradation of IκBα. |
| M6179 | Diethylmaleate | Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB. |
| M5371 | 5-Aminosalicylic acid | 5-aminosalicylic acid (Mesalamine) is a specific PPARγ agonist that also inhibits P21-activated kinase 1 (PAK1) and NF-κB. |
| M7588 | N-acetylcysteine amide | N-Acetylcysteine amide is a thiol antioxidant and neuroprotective agent that crosses cell membranes and the blood-brain barrier, has anti-inflammatory activity, and is able to modulate NF-κB activation, HIF-1α and ROS. |
| M29555 | NF-κΒ activator 2 | NF-κΒ activator 2 is a potent and orally active NF-ҡB activator, with an EC50 of 1.58 μM. NF-κΒ activator 2 induces SOD2 through increasing NF-ҡB expression and activation. NF-κΒ activator 2 can be used for the research of amyotrophic lateral sclerosis (ALS). |
| M25465 | B022 | B022 is a potent and selective NF-κB-inducing kinase (NIK) inhibitor with Ki of 4.2 nM and IC50 of 15.1 nM. B022 protects liver from toxin-induced inflammation, oxidative stress and injury. |
| M25407 | SN52 | SN52 is a novel potent, competitive, and cell-permeable inhibitor of nuclear factor-kappaB (NF-κB). SN52 is a variant of the SN50 peptide and inhibits the nuclear translocation of p52-RelB heterodimers. SN52 has a strong radiosensitization effect on prostate cancer cells. |
| M21470 | CDDO-dhTFEA | CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound that effectively activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB. |
| M21403 | CORM-3 | CORM-3 is a carbon monoxide-releasing molecule that attenuates nuclear ectopic NF-κB p65, reduces ROS production, and increases intracellular glutathione and superoxide dismutase levels.CORM-3 reduces the activation of NLRP3 inflammatory vesicles. |
| M19371 | Handelin | Handelin is a guaianolide dimer from Chrysanthemum boreale that has potent anti-inflammatory activity by down-regulating NF-κB signaling and pro-inflammatory cytokine production. |
| M19347 | Nimbolide | Nimbolide induces apoptosis through inactivation of NF-κB. Nimbolide inhibits CDK4/CDK6 kinase activity. Nimbolide suppresses the NF-κB, Wnt, PI3K-Akt, MAPK and JAK-STAT signaling pathways. |
| M19176 | Sappanone A | Sappanone A is a homoisoflavanone which exhibits anti-inflammatory effects via modulation of Nrf2 and NF-κB. |
| M18964 | Nervonic Acid | Nervonic Acid is a monounsaturated fatty acid with oral activity. Nervonic acid exerts anti-inflammatory activity by inhibiting NF-κB signaling. |
| M18713 | Chelidonic acid | Chelidonic acid is an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1. Chelidonic acid is a glutamate decarboxylase inhibitor, with a Ki of 1.2 μM. |
| M18255 | Hesperidin methylchalcone | Hesperidin methylchalcone is an orally active flavonoid that has analgesic, anti-inflammatory and antioxidant properties. Hesperidin methylchalcone exhibits vasoprotective activity. Hesperidin methylchalcone inhibits oxidative stress, cytokine production and NF-κB activation. |
| M17765 | Ginsenoside Rk3 | Ginsenoside Rk3 significantly inhibits TNF-α-induced NF-κB transcriptional activity, with an IC50 of 14.24±1.30 μM in HepG2 cells. |
| M16964 | Phyllanthin | Phyllanthin exhibits high antioxidative and hepatoprotective properties. |
| M14655 | Aurothioglucose | Aurothioglucose (Gold thioglucose) is a well known active-site inhibitor of TrxR1, inhibited TrxR1 activity in HeLa cell cytosol but had no effect on the viability of the cells. |
| M14612 | Tomatidine hydrochloride | Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. Tomatidine hydrochloride activates autophagy either in mammal cells or C elegans. |
| M14611 | Tomatidine | Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. Tomatidine activates autophagy either in mammal cells or C elegans. |
| M14609 | Stachydrine | Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibit the NF-κB signal pathway. |
| M14608 | Sinomenine | Sinomenine, an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-κB activation. Sinomenine also is an activator of μ-opioid receptor. |
| M14607 | Rocaglamide | Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. |
| M14604 | Isoliquiritin apioside | Isoliquiritin apioside significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. |
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