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Chelidonic acid

Cat. No. M18713

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Chelidonic acid Structure
Size Price Availability Quantity
20mg USD 30  USD30 In stock
50mg USD 40  USD40 In stock
100mg USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

Chelidonic acid is an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1. Chelidonic acid is a glutamate decarboxylase inhibitor, with a Ki of 1.2 μM.

Chelidonic acid (0.2, 2 mg/kg p.o.) attenuates allergic reaction induced by ovalbumin in mice.

Chemical Information
Molecular Weight 184.10
Formula C7H4O6
CAS Number 99-32-1
Solubility (25°C) DMSO 8 mg/mL
Water 2 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Shivanand S Malaganvi, et al. Heliyon. Experimental, DFT dimeric modeling and AIM study of H-bond-mediated composite vibrational structure of Chelidonic acid

[2] Elena Avdeeva, et al. Biomolecules. Chelidonic Acid and Its Derivatives from Saussurea Controversa: Isolation, Structural Elucidation and Influence on the Osteogenic Differentiation of Multipotent Mesenchymal Stromal Cells In Vitro

[3] Dhirendra Kumar Singh, et al. Int Immunopharmacol. Effects of chelidonic acid, a secondary plant metabolite, on mast cell degranulation and adaptive immunity in rats

[4] Hyun-Ja Jeong, et al. Exp Biol Med (Maywood). Chelidonic acid evokes antidepressant-like effect through the up-regulation of BDNF in forced swimming test

[5] T G Porter, et al. Biochem Pharmacol. Chelidonic acid and other conformationally restricted substrate analogues as inhibitors of rat brain glutamate decarboxylase

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Keywords: Chelidonic acid supplier, NF-κB, inhibitors, activators

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