All AbMole products are for research use only, cannot be used for human consumption.
B022 is a potent and selective NF-κB-inducing kinase (NIK) inhibitor with Ki of 4.2 nM and IC50 of 15.1 nM.
B022 protects liver from toxin-induced inflammation, oxidative stress and injury. B022 prevents NIK- or H2O2-induced β cell death and also ameliorates streptozotocin (STZ)-induced β cell death and hyperglycemia.
In vivo, B022 (30 mg/kg; intravenous injection; twice a day; for 10 days) treatment inhibits NIK-triggered liver inflammation and injury in STOP-NIK mice infected with cre adenoviruses.
| Molecular Weight | 397.88 |
| Formula | C19H16ClN5OS |
| CAS Number | 1202764-53-1 |
| Solubility (25°C) | DMSO >120 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related NF-κB Products |
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| PTD-p65-P1 Peptide TFA
PTD-p65-P1 Peptide TFA is a potent, selective nuclear transcription factor NF-κB inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis. |
| Narlumosbart
Narlumosbart is a human IgG4ҡ monoclonal antibody (mAb) that targets Receptor Activating Factor for Nuclear Factor κB Ligand (RANKL) and can be used in studies related to Giant Cell Tumor of Bone (GCTB). |
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Products are for research use only. Not for human use. We do not sell to patients.
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