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SN52 is a potent, competitive, and cell-permeable inhibitor of NF-κB.
SN52 is a variant of the SN50 peptide and inhibits the nuclear translocation of p52-RelB heterodimers. SN52 has a strong radiosensitization effect on prostate cancer cells with a low level of toxicity to normal prostate cells compared with SN50, which blocks nuclear import of the RelA:p50 dimer. SN52 has a strong radiosensitization effect on prostate cancer cells.
SN52 (40 μg/ml; 30 mins before DMXAA) inhibits DMXAA-induced nuclear translocation of RelB in BMDCs.
Both SN50 and SN52 enhance the radiosensitivity. SN52 seems to efficiently radiosensitize PC-3 cells at a low dose range of between 1 and 2 Gy, but its radiosensitization effect is slightly lower than that of SN50 at the high dose range of between 4 and 6 Gy.
Sequence: AAVALLPAVLLALLAPVQRKRRKALP
| Molecular Weight | 2749.43 |
| Formula | C128H230N38O28 |
| CAS Number | 1071173-56-2 |
| Solubility (25°C) | Water 25 mg/mL |
| Storage | -20°C, protect from light, dry, sealed |
[2] Giovanna M Bernal, et al. Cell Biosci. p52 signaling promotes cellular senescence
[3] Irene Saha, et al. Cell Immunol. RelB suppresses type I Interferon signaling in dendritic cells
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