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Sciadopitysin

Cat. No. M18884
Sciadopitysin Structure
Size Price Availability Quantity
5mg USD 115  USD115 In stock
10mg USD 195  USD195 In stock
20mg USD 320  USD320 In stock
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Quality Control & Documentation
Biological Activity

Sciadopitysin

Chemical Information
CAS Number 521-34-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Chujie Zhang, et al. J Biochem Mol Toxicol. Activation of PI3K/PKB/GSK-3β signaling by sciadopitysin protects cardiomyocytes against high glucose-induced oxidative stress and apoptosis

[2] Yuhua Cai, et al. Pharmacology. Protective Effect of Sciadopitysin against Isoproternol-Induced Myocardial Infarction in Rats

[3] Kwang Sik Suh, et al. J Appl Toxicol. The protective effects of sciadopitysin against methylglyoxal-induced cytotoxicity in cultured pancreatic β-cells

[4] E M Choi, et al. Free Radic Res. Sciadopitysin alleviates methylglyoxal-mediated glycation in osteoblastic MC3T3-E1 cells by enhancing glyoxalase system and mitochondrial biogenesis

[5] Kwang Sik Suh, et al. Food Chem Toxicol. Sciadopitysin protects osteoblast function via its antioxidant activity in MC3T3-E1 cells

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