Ginsenoside Rk1 is a high-temperature processed extract of ginseng. Ginsenoside Rk1 has anti-inflammatory effects and inhibits Jak2/Stat3 signaling pathway and NF-κB activation. Ginsenoside Rk1 has anti-tumor effects, anti-platelet aggregation activity, anti-inflammatory effects, anti-insulin resistance, renal protection, antibacterial effects, enhanced cognitive function, reduced lipid accumulation and prevention of osteoporosis. Ginsenoside Rk1 induces apoptosis by triggering intracellular reactive oxygen species (ROS) generation and blocking the PI3K/Akt pathway.
| Molecular Weight | 766.998 |
| Formula | C42H70O12 |
| CAS Number | 494753-69-4 |
| Form | Solid |
| Solubility (25°C) | 10 mM in DMSO |
| Storage | -20°C, protect from light |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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