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Schisandrol-B

Cat. No. M4249
Schisandrol-B Structure
Synonym:

Gomisin-A; Besigomsin; schizandrol-B; TJN-101; Wuweizi alcohol-B; Wuweizichun-B

Size Price Availability Quantity
20mg USD 130  USD130 In stock
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Quality Control
Biological Activity

Schisandrol-B is a major active constituent of Schisandra sphenanthera with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 416.46
Formula C23H28O7
CAS Number 58546-54-6
Purity 99.95%
Solubility DMSO
Storage at -20°C
References

[1] Jeong-Seok Kim, et al. Clin Exp Pharmacol Physiol. Gomisin A modulates aging progress via mitochondrial biogenesis in human diploid fibroblast cells

[2] Yiming Jiang, et al. Toxicol Sci. Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration

[3] Jing Jin, et al. Biopharm Drug Dispos. Enhancement of oral bioavailability of paclitaxel after oral administration of Schisandrol B in rats

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Schisandrol-B, Gomisin-A; Besigomsin; schizandrol-B; TJN-101; Wuweizi alcohol-B; Wuweizichun-B supplier, ROS, inhibitors

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