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Schisandrol B

Cat. No. M4249
Schisandrol B Structure
Synonym:

Gomisin-A; Besigomsin; schizandrol-B; TJN-101; Wuweizi alcohol-B; Wuweizichun-B

Size Price Availability Quantity
5mg USD 80  USD80 In stock
10mg USD 120  USD120 In stock
20mg USD 180  USD180 In stock
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Quality Control & Documentation
Biological Activity

Schisandrol B is a major active constituent of Schisandra sphenanthera with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities.

Chemical Information
Molecular Weight 416.46
Formula C23H28O7
CAS Number 58546-54-6
Solubility (25°C) DMSO ≥50 mg/mL (Need ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jeong-Seok Kim, et al. Clin Exp Pharmacol Physiol. Gomisin A modulates aging progress via mitochondrial biogenesis in human diploid fibroblast cells

[2] Yiming Jiang, et al. Toxicol Sci. Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration

[3] Jing Jin, et al. Biopharm Drug Dispos. Enhancement of oral bioavailability of paclitaxel after oral administration of Schisandrol B in rats

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Keywords: Schisandrol B, Gomisin-A; Besigomsin; schizandrol-B; TJN-101; Wuweizi alcohol-B; Wuweizichun-B supplier, NF-κB, inhibitors, activators


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