Schisandrol-B is a major active constituent of Schisandra sphenanthera with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Related ROS Products|
Cinnamtannin B-1 is a proanthocyanidin that has a variety of biological functions, including antioxidant effects. Cinnamtannin B-1 inhibits RANKL-induced osteoclasty and prevents osteoporosis induced by ovarian resection. Cinnamtannin B-1 inhibition can be used for the study of osteoporosis and colon cancer.
Euparin, a monomeric compound of Benzofuran, is a reactive oxygen species (ROS) inhibitor, which exhibits a moderate antioxidant activity, it also exhibits antifungal activity against Trichophyton mentagrophytes.
Acetylcysteine(N-acetyl-l-cysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor.
BAPTA is a calcium-specific aminopolycarboxylic acid.
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