Zingerone (Vanillylacetone) is a non-toxic methoxyphenol obtained from ginger. It has anti-inflammatory, anti-diabetes, anti-lipid allergy, anti-diarrhea, anti-spasticity and anti-tumor activities. Zingerone reduces oxidative stress and inflammation and down-regulates NF-κB signaling. Zingerone acts as an anti-mitotic agent and inhibits the growth of neuroblastoma.
| Molecular Weight | 194.23 |
| Formula | C11H14O3 |
| CAS Number | 122-48-5 |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Modje Kazemi, et al. Zingerone improves the immune responses in an animal model of breast cancer
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