Free shipping on all orders over $ 500

α-Lipoic Acid

Cat. No. M10982
α-Lipoic Acid Structure

Thioctic acid

Size Price Availability Quantity
500mg USD 60  USD60 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

α-Lipoic Acid is an antioxidant that is an important cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum stress (ER)-mediated apoptosis of liver cancer cells.

Chemical Information
Molecular Weight 206.33
Formula C8H14O2S2
CAS Number 1077-28-7
Solubility (25°C) DMSO ≥ 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Bahare Salehi, et al. Biomolecules. Insights on the Use of α-Lipoic Acid for Therapeutic Purposes

[2] Wei Liu, et al. Biomed Res Int. The Immunomodulatory Effect of Alpha-Lipoic Acid in Autoimmune Diseases

[3] S Kucukgoncu, et al. Obes Rev. Alpha-lipoic acid (ALA) as a supplementation for weight loss: results from a meta-analysis of randomized controlled trials

[4] Nikolaos Papanas, et al. Expert Opin Pharmacother. Efficacy of α-lipoic acid in diabetic neuropathy

[5] L Packer, et al. Free Radic Biol Med. alpha-Lipoic acid as a biological antioxidant

Related NF-κB Products
PTD-p65-P1 Peptide TFA

PTD-p65-P1 Peptide TFA is a potent, selective nuclear transcription factor NF-κB inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis.


Narlumosbart is a human IgG4ҡ monoclonal antibody (mAb) that targets Receptor Activating Factor for Nuclear Factor κB Ligand (RANKL) and can be used in studies related to Giant Cell Tumor of Bone (GCTB).


Ac2-26, an active N-terminal peptide of annexin A1 (AnxA1), attenuates ischemia-reperfusion-induced acute lung injury.

Mitogen-activated protein kinase 1

Mitogen-activated protein kinase 1 (MAPK1) can activate the downstream p38/NF-κB pathway.

IKKγ NBD Inhibitory Peptide

IKKγ NBD Inhibitory Peptide is a highly specific inhibitor NF-κB inhibitor.

Abmole Inhibitor Catalog

Keywords: α-Lipoic Acid, Thioctic acid supplier, NF-κB, inhibitors, activators

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.