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NIK SMI1

Cat. No. M9949
NIK SMI1 Structure
Synonym:

NIK-SMI1

Size Price Availability Quantity
5mg USD 550  USD550 In stock
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Quality Control
  • Current batch:
  • Purity >98.5%
  • COA
  • MSDS
Biological Activity

NIK SMI1 is a highly selective and potent NF-κB-inducing kinase (NIK) inhibitor. NIK SMI1 exhibits selective inhibition of LTβR-dependent p52 translocation and transcription of NF-κB2 related genes. NIK SMI1 inhibits BAFF signaling and reduces splenic marginal zone B cells in vivo.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 365.38
Formula C20H19N3O4
CAS Number 1660114-31-7
Purity >98.5%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
References

[1] Jiang Wang, et al. NIK inhibitor impairs chronic periodontitis via suppressing non-canonical NF-κB and osteoclastogenesis

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Keywords: NIK SMI1, NIK-SMI1 supplier, NF-κB, inhibitors

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