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Helenalin acetate 

Cat. No. M27643

All AbMole products are for research use only, cannot be used for human consumption.

Helenalin acetate  Structure

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Quality Control & Documentation
Biological Activity

Helenalin acetate, a natural NF-κB inhibitor, is a potent C/EBPβ inhibitor. Helenalin acetate effectively inhibits C/EBPβ at least 10 times higher than that for NF-κB (EC50 values were determined between 0.1 and 0.4 μM for C/EBPβ). Helenalin acetate has anti-inflammatory and anticancer activities.

Chemical Information
Molecular Weight 304.34
Formula C17H20O5
CAS Number 10180-86-6
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Franziska M Jürgens, et al. Metabolites. In Vitro Metabolism of Helenalin Acetate and 11α,13-Dihydrohelenalin Acetate: Natural Sesquiterpene Lactones from Arnica

[2] Anke Jakobs, et al. J Biol Chem. Helenalin Acetate, a Natural Sesquiterpene Lactone with Anti-inflammatory and Anti-cancer Activity, Disrupts the Cooperation of CCAAT Box/Enhancer-binding Protein β (C/EBPβ) and Co-activator p300

[3] J Malarz, et al. Planta Med. Helenalin Acetate in in vitro Propagated Plants of Arnica montana

[4] T J Schmidt. Planta Med. Glutathione adducts of helenalin and 11 alpha,13-dihydrohelenalin acetate inhibit glutathione S-transferase from horse liver

[5] B M Hausen. Hautarzt. [Arnica allergy]

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Keywords: Helenalin acetate  supplier, NF-κB, inhibitors, activators

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