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MnTBAP chloride 

Cat. No. M30290

All AbMole products are for research use only, cannot be used for human consumption.

MnTBAP chloride  Structure

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Quality Control & Documentation
Biological Activity

MnTBAP chloride is a superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. MnTBAP chloride is a manganic porphyrin complex and has anti-oxidative property. MnTBAP chloride mediates anti-inflammatory effects through upregulation of BMPR-II and inhibition of the NFκB signaling. MnTBAP chloride has the potential for the fibrotic response in chronic kidney diseases (CKDs) research.

Chemical Information
Molecular Weight 879.15
Formula C48H28ClMnN4O8
CAS Number 55266-18-7
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic) 0.5 M NaOH : 20 mg/mL (ultrasonic) 1M NaOH : 10 mg/mL (ultrasonic and adjust pH to 8 with NaOH)
Storage -20°C, dry, sealed
References

[1] Sergei Kiskurno, et al. Respir Physiol Neurobiol. Antioxidant MnTBAP does not protect adult mice from neonatal hyperoxic lung injury

[2] Rajkumar Venkatadri, et al. J Cell Physiol. MnTBAP Inhibits Bleomycin-Induced Pulmonary Fibrosis by Regulating VEGF and Wnt Signaling

[3] Jing Yu, et al. Oxid Med Cell Longev. MnTBAP Therapy Attenuates Renal Fibrosis in Mice with 5/6 Nephrectomy

[4] Madathilparambil V Suresh, et al. Surgery. The protective role of MnTBAP in oxidant-mediated injury and inflammation in a rat model of lung contusion

[5] Jacob Lackovic, et al. J Neurosci. Peroxynitrite Contributes to Behavioral Responses, Increased Trigeminal Excitability, and Changes in Mitochondrial Function in a Preclinical Model of Migraine

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Keywords: MnTBAP chloride  supplier, NF-κB, inhibitors, activators

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