PKUMDL-LC-101-D04 (GPX4-Activator-1d4) is a potent ferroptosis regulator glutathione peroxidase 4 (GPX4) allosteric activator (pEC50=4.7). PKUMDL-LC-101-D04 increases GPX4 activity to 150% at 20 μM in the cell-free assay and 61 μM in cell extracts.
| Molecular Weight | 378.94 |
| Formula | C14H23ClN4O2S2 |
| CAS Number | 2143896-83-5 |
| Form | Solid |
| Storage | -20°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Glutathione Peroxidase Products |
|---|
| GPX4-IN-4
GPX4-IN-4 is a potent GPX4 inhibitor. |
| GPX4-IN-6
GPX4-IN-6 is a GPX4 covalent inhibitor with an IC50 value of 0.13 μM. |
| GPX4-IN-5
GPX4-IN-5 is a GPX4 covalent inhibitor with an IC50 value of 0.12 μM. |
| NC-R17
NC-R17 is a RSL3-based noncovalent GPX4 degrader, involving in Ferroptosis. |
| Moracin N
Moracin N is a ferroptosis inhibitor that can be isolated from mulberry leaf. |
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