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NBDHEX 

Cat. No. M30612

All AbMole products are for research use only, cannot be used for human consumption.

NBDHEX  Structure
Size Price Availability Quantity
5mg USD 84  USD84 In stock
10mg USD 120  USD120 In stock
25mg USD 240  USD240 In stock
50mg USD 380  USD380 In stock
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Quality Control & Documentation
Biological Activity

NBDHEX is a potent glutathione S-transferase P1-1 (GSTP1-1) inhibitor. NBDHEX induces apoptosis of tumor cells. NBDHEX acts as an anticancer agent by inhibiting GSTs catalytic activity, avoiding inconvenience of the inhibitor extrusion from the cell by specific pumps and disrupting the interaction between the GSTP1-1 and key signaling effectors. NBDHEX can also act as late-phase autophagy inhibitor.

Chemical Information
Molecular Weight 297.33
Formula C12H15N3O4S
CAS Number 787634-60-0
Form Solid
Solubility (25°C) DMSO 120 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Huanhuan Sha, et al. Cancer Med. NBDHEX re-sensitizes adriamycin-resistant breast cancer by inhibiting glutathione S-transferase pi

[2] Giulia Siciliano, et al. Pharmaceuticals (Basel). The Nitrobenzoxadiazole Derivative NBDHEX Behaves as Plasmodium falciparum Gametocyte Selective Inhibitor with Malaria Parasite Transmission Blocking Activity

[3] Huanhuan Sha, et al. J Cancer. In Vitro and in Vivo Efficacy of NBDHEX on Gefitinib-resistant Human Non-small Cell Lung Cancer

[4] Huan-Huan Sha, et al. Biosci Rep. 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio) hexanol: a promising new anticancer compound

[5] Lucio Tentori, et al. Eur J Cancer. The glutathione transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) increases temozolomide efficacy against malignant melanoma

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  Catalog
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Keywords: NBDHEX  supplier, Glutathione Peroxidase, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



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