Inhibitor/Activator
| Cat.No. | Name | Information |
|---|---|---|
| M30612 | NBDHEX | NBDHEX is a potent glutathione S-transferase P1-1 (GSTP1-1) inhibitor. NBDHEX induces apoptosis of tumor cells. NBDHEX acts as an anticancer agent by inhibiting GSTs catalytic activity, avoiding inconvenience of the inhibitor extrusion from the cell by specific pumps and disrupting the interaction between the GSTP1-1 and key signaling effectors. NBDHEX can also act as late-phase autophagy inhibitor. |
| M30251 | 4-Aminobenzohydrazide | 4-Aminobenzohydrazide is an irreversible MPO myeloperoxidase inhibitor with an IC50 of 0.3 µM. It is used for the research of subacute stroke. |
| M29297 | PKUMDL-LC-101-D04 | PKUMDL-LC-101-D04 (GPX4-Activator-1d4) is a potent ferroptosis regulator glutathione peroxidase 4 (GPX4) allosteric activator (pEC50=4.7). PKUMDL-LC-101-D04 increases GPX4 activity to 150% at 20 μM in the cell-free assay and 61 μM in cell extracts. |
| M55894 | N-Acetyl lysyltyrosylcysteine amide | N-Acetyl lysyltyrosylcysteine amide is a potent, reversible, specific, and non-toxic tripeptide inhibitor of myeloperoxidase (MPO). |
| M42431 | GPX4-IN-4 | GPX4-IN-4 is a potent GPX4 inhibitor. |
| M42430 | GPX4-IN-6 | GPX4-IN-6 is a GPX4 covalent inhibitor with an IC50 value of 0.13 μM. |
| M42429 | GPX4-IN-5 | GPX4-IN-5 is a GPX4 covalent inhibitor with an IC50 value of 0.12 μM. |
| M42428 | NC-R17 | NC-R17 is a RSL3-based noncovalent GPX4 degrader, involving in Ferroptosis. |
| M41345 | Moracin N | Moracin N is a ferroptosis inhibitor that can be isolated from mulberry leaf. |
| M41344 | Lepadin E | Lepadin E is a significantly cytotoxic ferroptosis inducer that induces iron death through the classical p53-SLC7A11-GPX4 pathway. |
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