Glutathione Peroxidase Glutathione peroxidases (GPX)

Inhibitor/Activator

Cat.No.	Name	Information
M29297	PKUMDL-LC-101-D04	PKUMDL-LC-101-D04 (GPX4-Activator-1d4) is a potent ferroptosis regulator glutathione peroxidase 4 (GPX4) allosteric activator (pEC50=4.7). PKUMDL-LC-101-D04 increases GPX4 activity to 150% at 20 μM in the cell-free assay and 61 μM in cell extracts.
M42431	GPX4-IN-4	GPX4-IN-4 is a potent GPX4 inhibitor.
M42430	GPX4-IN-6	GPX4-IN-6 is a GPX4 covalent inhibitor with an IC50 value of 0.13 μM.
M42429	GPX4-IN-5	GPX4-IN-5 is a GPX4 covalent inhibitor with an IC50 value of 0.12 μM.
M42428	NC-R17	NC-R17 is a RSL3-based noncovalent GPX4 degrader, involving in Ferroptosis.
M41345	Moracin N	Moracin N is a ferroptosis inhibitor that can be isolated from mulberry leaf.
M41344	Lepadin E	Lepadin E is a significantly cytotoxic ferroptosis inducer that induces iron death through the classical p53-SLC7A11-GPX4 pathway.
M30612	NBDHEX	NBDHEX is a potent glutathione S-transferase P1-1 (GSTP1-1) inhibitor. NBDHEX induces apoptosis of tumor cells. NBDHEX acts as an anticancer agent by inhibiting GSTs catalytic activity, avoiding inconvenience of the inhibitor extrusion from the cell by specific pumps and disrupting the interaction between the GSTP1-1 and key signaling effectors. NBDHEX can also act as late-phase autophagy inhibitor.
M30251	4-Aminobenzohydrazide	4-Aminobenzohydrazide is an irreversible MPO myeloperoxidase inhibitor with an IC50 of 0.3 µM. It is used for the research of subacute stroke.