All AbMole products are for research use only, cannot be used for human consumption.
Rosuvastatin (Crestor) is a member of the compound class of statins, used to treat high cholesterol and related conditions, and to prevent cardiovascular disease. Rosuvastatin is a competitive inhibitor of the enzyme HMG-CoA reductase, having a mechanism of action similar to that of other statins.
Atherosclerosis. 2019 Nov;290:19-30.
Lysophosphatidic acid decreased macrophage foam cell migration correlated with downregulation of fucosyltransferase 8 via HNF1α.
Rosuvastatin calcium purchased from AbMole
Pak J Pharm Sci. 2016 May;29(3 Suppl):1043-51.
Chromatographic resolution of drug analogues: 3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitors (statins)
Rosuvastatin calcium purchased from AbMole
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Source | Pak J Pharm Sci (2016). Figure 1. Rosuvastatin calcium (Abmole Bioscience) |
| Method | HPLC chromatogram | |
| Cell Lines | ||
| Concentrations | 200μg/ml | |
| Incubation Time | ||
| Results | The results summarized in (table 1) obtained for pravastatin, rosuvastatin, pitavastatin, atorvastatin, fluvastatin, lovastatin and simvastatin were comparable with the corresponding labeled amounts. |
| Molecular Weight | 500.57 |
| Formula | C44H54CaF2N6O12S2 |
| CAS Number | 147098-20-2 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Yvette N Lamb. Rosuvastatin/Ezetimibe: A Review in Hypercholesterolemia
[4] Gurpreet S Wander, et al. Rosuvastatin: Role in Secondary Prevention of Cardiovascular Disease
[5] Francesca Cortese, et al. Rosuvastatin: Beyond the cholesterol-lowering effect
| Related HMG-CoA Reductase Products |
|---|
| Mevastatin
Mevastatin is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself. |
| Clinofibrate
Clinofibrate inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR) with IC50 of 0.47 mM, is a lipid-lowering agent used for controlling high cholesterol and triacylglyceride levels in the blood. |
| Cerivastatin sodium
Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin sodium reduces low-density lipoprotein cholesterol levels. Cerivastatin sodium also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect. |
| 2-Hydroxy atorvastatin calcium salt
2-Hydroxy atorvastatin calcium salt is the hydroxyl metabolite of Atorvastatin calcium salt, an inhibitor of HMG-CoA reductase that inhibits cholesterol production with an IC50 value of 8 nM. |
| 4-Hydroxy atorvastatin calcium salt
4-Hydroxy atorvastatin calcium salt is the hydroxyl metabolite of Atorvastatin calcium salt, an inhibitor of HMG-CoA reductase that inhibits cholesterol production with an IC50 value of 8 nM. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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