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Rosuvastatin calcium

Cat. No. M2283
Rosuvastatin calcium Structure
Synonym:

Crestor

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 33.6  USD42 In stock
10mg USD 35.2  USD44 In stock
50mg USD 65.6  USD82 In stock
100mg USD 83.2  USD104 In stock
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Quality Control
Biological Activity

Rosuvastatin (Crestor) is a member of the compound class of statins, used to treat high cholesterol and related conditions, and to prevent cardiovascular disease. Rosuvastatin is a competitive inhibitor of the enzyme HMG-CoA reductase, having a mechanism of action similar to that of other statins.

Product Citations
Customer Product Validations & Biological Datas
Source Pak J Pharm Sci (2016). Figure 1. Rosuvastatin calcium (Abmole Bioscience)
Method HPLC chromatogram
Cell Lines
Concentrations 200μg/ml
Incubation Time
Results The results summarized in (table 1) obtained for pravastatin, rosuvastatin, pitavastatin, atorvastatin, fluvastatin, lovastatin and simvastatin were comparable with the corresponding labeled amounts.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 500.57
Formula C44H54CaF2N6O12S2
CAS Number 147098-20-2
Purity 99.62%
Solubility DMSO 45 mg/mL
Storage at -20°C
References

[1] Xuan Jin, et al. Efficacy and safety of co-administered telmisartan/amlodipine and rosuvastatin in subjects with hypertension and dyslipidemia

[2] Yvette N Lamb. Rosuvastatin/Ezetimibe: A Review in Hypercholesterolemia

[3] Larysa Strilchuk, et al. An overview of rosuvastatin/ezetimibe association for the treatment of hypercholesterolemia and mixed dyslipidemia

[4] Gurpreet S Wander, et al. Rosuvastatin: Role in Secondary Prevention of Cardiovascular Disease

[5] Francesca Cortese, et al. Rosuvastatin: Beyond the cholesterol-lowering effect

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Keywords: Rosuvastatin calcium, Crestor supplier, Autophagy, inhibitors

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