Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin sodium reduces low-density lipoprotein cholesterol levels. Cerivastatin sodium also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect.
| Molecular Weight | 481.53 |
| Formula | C26H33FNNaO5 |
| CAS Number | 143201-11-0 |
| Form | Solid |
| Solubility (25°C) | Water 100 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage | -20°C, protect from light, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Stephen P Adams, et al. Cochrane Database Syst Rev. Cerivastatin for lowering lipids
[2] A Cheng-Lai. Heart Dis. Cerivastatin
[3] W Mück. Clin Pharmacokinet. Clinical pharmacokinetics of cerivastatin
| Related HMG-CoA Reductase Products |
|---|
| Fluvastatin
Fluvastatin is the first fully synthesized, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM.Fluvastatin protects vascular smooth muscle cells from oxidative stress through an Nrf2-dependent antioxidant pathway. |
| Pravastatin lactone
Pravastatin lactone is a potent HMG-CoA inhibitor. |
| HMG-CoA Reductase-IN-1
HMG-CoA Reductase-IN-1 is a HMG-CoA reductase inhibitor. |
| Ganomycin I
Ganomycin I is a dual inhibitor of α-Glucosidase and HMG-CoA reductase. |
| Ganoderenic acid K
Ganoderenic acid K is a natural product, that can be isolated from fruiting bodies of Ganoderma lucidum. |
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