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Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin sodium reduces low-density lipoprotein cholesterol levels. Cerivastatin sodium also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect.
| Molecular Weight | 481.53 |
| Formula | C26H33FNNaO5 |
| CAS Number | 143201-11-0 |
| Form | Solid |
| Solubility (25°C) | Water 100 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage | -20°C, protect from light, sealed |
[1] Stephen P Adams, et al. Cochrane Database Syst Rev. Cerivastatin for lowering lipids
[2] A Cheng-Lai. Heart Dis. Cerivastatin
[3] W Mück. Clin Pharmacokinet. Clinical pharmacokinetics of cerivastatin
| Related HMG-CoA Reductase Products |
|---|
| Dalvastatin
Dalvastatin (RG-12561) inhibitor of HMG-CoA reductase and cholesterol-lowering synthesis. |
| (3S,5R)-Fluvastatin sodium
(3S,5R)-Fluvastatin sodium ((3S,5R)-XU 62-320) is the (3S,5R)-enantiomer of Fluvastatin. |
| Fluvastatin
Fluvastatin is the first fully synthesized, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM.Fluvastatin protects vascular smooth muscle cells from oxidative stress through an Nrf2-dependent antioxidant pathway. |
| Pravastatin lactone
Pravastatin lactone is a potent HMG-CoA inhibitor. |
| HMG-CoA Reductase-IN-1
HMG-CoA Reductase-IN-1 is a HMG-CoA reductase inhibitor. |
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