All AbMole products are for research use only, cannot be used for human consumption.
Rosiglitazone, also known as BRL 49653, is a potent and selective agonist for PPARγ (Peroxisome proliferator-activated receptor) with an EC50 of 43 nM. PPARγ plays a functional role in adipogenesis, it belongs to a group of nuclear receptor proteins that are essential to the regulation of cellular differentiation, development and metabolism. Rosiglitazone binds to the PPAR receptors in fat cells and making the cells more responsive to insulin. It activates luciferase-based expression constructs PPARγ1 and PPARγ2 with EC50 values of approximately 30 nM and 100 nM, respectively. Rosiglitazone induced adipocyte differentiation in pluripotent C3H10T1/2 stem cells. Rosiglitazone suppressed the activity of complex I of the MRC in ob/ob mice, but did not affect beta-oxidation.
Food Res Int. 2024 Jul 30.
Optimization of differentiation conditions for porcine adipose-derived mesenchymal stem cells and analysis of fatty acids in cultured fat
Rosiglitazone purchased from AbMole
Adv Sci (Weinh). 2023 Mar 27;e2207224.
Hypoxia Drives Material‐Induced Heterotopic Bone Formation by Enhancing Osteoclastogenesis via M2/Lipid‐Loaded Macrophage Axis
Rosiglitazone purchased from AbMole
Biomaterials. 2023 Oct 17.
The genetic background determines material-induced bone formation through the macrophage-osteoclast axis
Rosiglitazone purchased from AbMole
Food Res Int. 2023 Jan 17;112486.
Evaluation the food safety of cultured fat via detection of residues of adipogenic differentiation cocktail in cultured fat with high performance liquid chromatography and enzyme-linked immunosorbent assay
Rosiglitazone purchased from AbMole
Food Res Int. 2023 Feb 14.
N-acetylcysteine promotes the proliferation of porcine adipose-derived stem cells during in vitro long-term expansion for cultured meat production
Rosiglitazone purchased from AbMole
J Agric Food Chem. 2023 Feb 24.
Preparation and Quality Evaluation of Cultured Fat
Rosiglitazone purchased from AbMole
Food Res Int. 2022 Oct;160:111636.
Production of cultured fat with peanut wire-drawing protein scaffold and quality evaluation based on texture and volatile compounds analysis
Rosiglitazone purchased from AbMole
Food Res Int. 2022 Sep 14.
Identification of porcine adipose progenitor cells by fluorescence-activated cell sorting for the preparation of cultured fat by 3D bioprinting
Rosiglitazone purchased from AbMole
Biosci Biotechnol Biochem. 2022 Feb 24;86(3):331-339.
BRCC36 promotes intestinal mucosal barrier injury caused by BMP2 after ischemia reperfusion via inhibiting PPARγ signaling
Rosiglitazone purchased from AbMole
| Molecular Weight | 357.43 |
| Formula | C18H19N3O3S |
| CAS Number | 122320-73-4 |
| Solubility (25°C) | DMSO 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related PPAR Products |
|---|
| GQ-16
GQ-16 is a moderate affinity ligand for the ligand-binding domain (LBD) of PPARγ, exhibiting a Ki of 160 nM. |
| SR10221
SR10221, a noncovalent inverse agonist of PPARγ, represses downstream PPARγ target genes leading to growth inhibition in bladder cancer cell lines. |
| Amorfrutin B
Amorfrutin B is a highly potent natural peroxisome proliferation-activated receptor γ (PPARγ) agonist with oral activity with Ki values of 19 nM and EC50 values of 73 nM, respectively. |
| Netoglitazone
Netoglitazone is a dual agonist of PPARα and PPARγ with antihyperglycemic activity. |
| DSO-5a
DSO-5a is a potent, selective, orally active BB3 agonist. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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