All AbMole products are for research use only, cannot be used for human consumption.
ZLN005 is a novel transcriptional regulator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). ZLN005 stimulates the expression of PGC-1α and downstream genes in skeletal muscle cells, improving glucose utilization and fatty acid oxidation at a concentration of 20 μM. ZLN005 increased PGC-1α and downstream gene transcription in skeletal muscle, whereas hepatic PGC-1α and gluconeogenesis genes were reduced. ZLN005 increased fat oxidation and improved the glucose tolerance, pyruvate tolerance, and insulin sensitivity of diabetic db/db mice. ZLN005 selectively elevated the expression of PGC-1α in myotubes and skeletal muscle and exerted promising therapeutic effects for treating type 2 diabetes.
J Hazard Mater. 2024 Apr 16;471:134331.
ZLN005 alleviates PBDE-47 induced impairment of mitochondrial translation and neurotoxicity through PGC-1α/ERRα axis
ZLN005 purchased from AbMole
Neuroscience. 2023 May 3;521:134-147.
Resveratrol Attenuates the Disruption of Lipid Metabolism Observed in Amyloid Precursor Protein/Presenilin 1 Mouse Brains and Cultured Primary Neurons Exposed to Aβ
ZLN005 purchased from AbMole
Toxicol Sci. 2022 Oct 21;kfac110.
PBDE-47 induces impairment of mitochondrial biogenesis and subsequent neurotoxicity through miR-128-3p/PGC-1α axis
ZLN005 purchased from AbMole
Am J Pathol. 2020 Apr 11;S0002-9440(20)30191-7.
Silent Mating-Type Information Regulation 2 Homolog 1 Attenuates the Neurotoxicity Associated With Alzheimer Disease via a Mechanism Which May Involve Regulation of Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-α
ZLN005 purchased from AbMole
 |
Source | Diabetes (2013). Figure 1. ZLN005 |
| Method | qRT-PCR | |
| Cell Lines | HEK293 cells | |
| Concentrations | 10 μmol/L | |
| Incubation Time | 24 h | |
| Results | The mRNA levels of GLUT4, NRF1, estrogen-related receptor a (ERRa), cytochrome c oxidase 5b (cox5b), and acyl-CoA oxidase were increased by ZLN005 (10 μmol/L). |
| Molecular Weight | 250.34 |
| Formula | C17H18N2 |
| CAS Number | 49671-76-3 |
| Solubility (25°C) | DMSO 35 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related PPAR Products |
|---|
| GQ-16
GQ-16 is a moderate affinity ligand for the ligand-binding domain (LBD) of PPARγ, exhibiting a Ki of 160 nM. |
| SR10221
SR10221, a noncovalent inverse agonist of PPARγ, represses downstream PPARγ target genes leading to growth inhibition in bladder cancer cell lines. |
| Amorfrutin B
Amorfrutin B is a highly potent natural peroxisome proliferation-activated receptor γ (PPARγ) agonist with oral activity with Ki values of 19 nM and EC50 values of 73 nM, respectively. |
| Netoglitazone
Netoglitazone is a dual agonist of PPARα and PPARγ with antihyperglycemic activity. |
| DSO-5a
DSO-5a is a potent, selective, orally active BB3 agonist. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
