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Bezafibrate

Cat. No. M2455
Bezafibrate Structure
Synonym:

BM15075

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
100mg USD 32  USD32 In stock
200mg USD 48  USD48 In stock
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Quality Control & Documentation
Biological Activity

Bezafibrate is the first clinically tested dual and pan-PPAR co-agonism.

Chemical Information
Molecular Weight 361.82
Formula C19H20ClNO4
CAS Number 41859-67-0
Solubility (25°C) DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jessica Katharine Dyson, et al. Bezafibrate for the Treatment of Cholestatic Pruritus: Time for a Change in Management?

[2] Christophe Corpechot, et al. A Placebo-Controlled Trial of Bezafibrate in Primary Biliary Cholangitis

[3] V De Marco, et al. Therapy of Canine Hyperlipidemia with Bezafibrate

[4] No authors listed. Drug Ther Bull. Bezafibrate

[5] E Kanterewicz, et al. Bezafibrate induced rhabdomyolysis

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  Catalog
Abmole Inhibitor Catalog




Keywords: Bezafibrate, BM15075 supplier, PPAR, inhibitors, activators


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