Inhibitor/Activator
| Cat.No. | Name | Information |
|---|---|---|
| M9747 | Lanifibranor | Lanifibranor (IVA-337) is a peroxisome proliferator-activated receptors (PPAR) agonist, with EC50s of 1.5, 0.87 and 0.21 μM for human PPARα, PPARσ and PPARγ, respectively. |
| M6723 | Fenofibrate | Fenofibrate is a selective PPARα agonist with an EC50 of 30 μM. Fenofibrate inhibited cytochrome P450 subtype, with IC50 of 0.2, 0.7, 9.7, 4.8, and 142.1 μM for CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4, respectively. |
| M5940 | Rosiglitazone HCl | Rosiglitazone HCl is a hypoglycemic compound that stimulates insulin secretion by binding to PPAR receptors in fat cells. |
| M5927 | Retinoic acid | Retinoic acid is A metabolite of vitamin A and plays an important role in cell growth, differentiation and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors with an IC50 of 14 nM for RARα/β/γ. The Kd value of Retinoic acid combined with PPARβ/δ is 17 nM. Retinoic acid inhibits the transcription factor Nrf2 by activating Retinoic acid receptors. |
| M5878 | Pioglitazone HCl | Pioglitazone HCl is a selective peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist, used to treat diabetes. |
| M5641 | Fenofibric acid | Fenofibric acid is a fibrate that acts as a lipid-lowering agent, decreasing low-density lipoprotein cholesterol and triglycerides. |
| M4155 | Soyosaponin-Ab | Soyasaponin Ab is a soy saponin that exerts anti-obesity effects by down-regulating PPARγ in 3T3-L1 adipocytes. |
| M3283 | Pioglitazone | Pioglitazone (U 72107) is a selective peroxisome proliferator-activated receptor gamma stimulator. |
| M3044 | T0070907 | T0070907 is a potent and selective PPARγ inhibitor with IC50 of 1 nM, with a >800-fold selectivity over PPARα and PPARδ. |
| M2748 | GW9662 | GW9662 is a selective PPAR antagonist for PPARγ with IC50 of 3.3 nM, with at least 100 to 1000-fold functional selectivity in cells with PPARγ versus PPARα and PPARδ. |
| M2747 | GW7647 | GW7647 is a potent and highly selective PPARα agonist with EC50 of 6 nM. |
| M2746 | GW6471 | GW6471 is an antagonist of PPARα with IC50 of 0.24 μM. |
| M2335 | ZLN005 | ZLN005 is a novel and potent small molecule PGC-1α transcriptional activator. |
| M1894 | Rosiglitazone | Rosiglitazone (BRL 49653) is an orally active selective PPARγ agonist (EC50=60 nM, Kd=40 nM). Rosiglitazone is an TRPC5 activator (EC50=30 μM) and TRPM3 inhibitor. |
| M1880 | WY 14643 (Pirinixic Acid) | WY 14643 (Pirinixic Acid) is a potent and selective, peroxisome proliferator-activated receptor-α (PPARα) agonist. |
| M45357 | Seladelpar | Seladelpar is a potent, orally active, specific PPAR-δ agonist with an EC50 of 2 nM. |
| M41585 | FX-909 | FX-909 is a covalent peroxisome proliferator-activated receptor gamma (PPARG) inverse agonist. |
| M31285 | Triphenyl phosphate | Triphenyl phosphate (TPP, triphenyl phosphate) is an organophosphate esters (OPEs), as well as a selective PPARγ regulator, and induces macrophage dysfunction through activation of the TLR4-mediated ERK/NF-κB signaling pathway, which induces apoptosis in mouse hepatocytes. |
| M31125 | Monoethyl Phthalate | Monoethyl Phthalate is a metabolite of diethyl phthalate that acts as an agonist for estrogenic compounds and PPARγ at lower concentrations. |
| M21446 | AZD-9574 | AZD-9574 is a best-in-class, potent, blood-brain barrier permeable PARP1 inhibitor that exhibits >8000-fold selectivity for PARP1 over PARP2/3/5a/6.AZD-9574 selectively inhibits PARP1 at the SSB site.AZD-9574 is an anticancer AZD-9574 is an anticancer compound that can be used in HRD+ breast cancer and advanced solid malignant tumor studies. |
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