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Pioglitazone

Cat. No. M3283
Pioglitazone Structure
Synonym:

U 72107

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mg USD 55  USD55 In stock
50mg USD 115  USD115 In stock
100mg USD 155  USD155 In stock
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Quality Control & Documentation
Biological Activity

Pioglitazone (U 72107) is a selective peroxisome proliferator-activated receptor gamma stimulator. Pioglitazone (U 72107) selectively stimulates the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-γ) and to a lesser extent PPAR-α. Pioglitazone (Actos) modulates the transcription of the insulin-sensitive genes involved in the control of glucose and lipid metabolism in the muscle, adipose tissue, and the liver. As a result, pioglitazone (U 72107) reduces insulin resistance in the liver and peripheral tissues. Pioglitazone (U 72107) increases the expense of insulin-dependent glucose. Pioglitazone (U 72107) decreases withdrawal of glucose from the liver. Pioglitazone (U 72107) reduces quantity of glucose, insulin and glycated hemoglobin in the bloodstream.

Product Citations
Customer Product Validations & Biological Datas
Source J Cell Mol Med (2020 Jun). Figure 2. Pioglitazone (Abmole Bioscience, Houston, TX, USA)
Method drug treatments
Cell Lines Neurons
Concentrations 10 μmol/L
Incubation Time 24 hours
Results Compared to the DMSO group, a 24-hour treatment with pioglitazone increased the levels of the ZAG protein (1.013 ± 0.135 vs 0.654 ± 0.090, P = 0.004, n = 4) and AZGP1 mRNA (1.474 ± 0.078 vs 1, P = 0.003, n = 3) (Figure 2B,C), while GW9662 significantly decreased the levels of the ZAG protein (0.361 ± 0.097 vs 0.654 ± 0.090, P = 0.013, n = 4) and AZGP1 mRNA (0.482 ± 0.153 vs 1, P = 0.002, n = 3) (Figure 2B,C).
Chemical Information
Molecular Weight 356.44
Formula C19H20N2O3S
CAS Number 111025-46-8
Solubility (25°C) DMSO 30 mg/mL (Need ultrasonic and warming)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] David Karsek. Pioglitazone

[2] Ralph A DeFronzo, et al. Pioglitazone: The forgotten, cost-effective cardioprotective drug for type 2 diabetes

[3] Huilin Tang, et al. Pioglitazone and bladder cancer risk: a systematic review and meta-analysis

[4] Sanjay Kalra, et al. Pioglitazone

[5] Hiroyoshi Yokoi. Pioglitazone

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Keywords: Pioglitazone, U 72107 supplier, PPAR, inhibitors, activators


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