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SR1664 blocks Cdk5-dependent PPARγ phosphorylation (IC50 = 80 nM; Ki = 28.67 nM) without exhibiting PPARγ agonist activity. SR1664 does not inhibit Cdk5-dependent phosphorylation of Rb. SR1664 reduces fasting insulin levels and improves insulin sensitivity in a mouse model of diabetes.
| Molecular Weight | 547.6 |
| Formula | C33H29N3O5 |
| CAS Number | 1338259-05-4 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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