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Ciprofibrate is a peroxisome proliferator-activated receptor α (PPARα) agonist. Ciprofibrate belongs to the second generation of fibric acid derivatives. Ciprofibrate can induce proliferation of peroxisomes in liver cells of rats. Ciprofibrate treatment effectively reduced triglyceride-rich particles and non-HDL cholesterol, and significantly increased HDL cholesterol, proving its effectiveness in patients with low HDL cholesterol and type IV Frederickson's hyperlipidemia.
| Molecular Weight | 289.15 |
| Formula | C13H14Cl2O3 |
| CAS Number | 52214-84-3 |
| Solubility (25°C) | DMSO 50 mg/mL Ethanol 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related PPAR Products |
|---|
| WY 14643 (Pirinixic Acid)
WY 14643 (Pirinixic Acid) is a potent and selective, peroxisome proliferator-activated receptor-α (PPARα) agonist. |
| GSK 3787
GSK3787 is an orally available selective peroxisome proliferator-activated receptor δ (PPARδ) antagonist (pIC50 = 6.6). |
| ZLN005
ZLN005 is a novel and potent small molecule PGC-1α transcriptional activator. |
| Bezafibrate
Bezafibrate is the first clinically tested dual and pan-PPAR co-agonism. |
| Clofibric Acid (PCIB)
Clofibric acid (PCIB, Chlorofibrinic acid), a lipid fiber modulator Clofibrate, Etofibrate and Etofyllinclofibrate active metabolites, is a PPARα excitant, has the effect of lowering blood lipid. Clofibric acid is also a herbicide. |
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