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Clofibric Acid (PCIB)

Cat. No. M2529

All AbMole products are for research use only, cannot be used for human consumption.

Clofibric Acid (PCIB) Structure
Synonym:

2-(4-Chlorophenoxy)-2-methylpropionic acid; Chlorofibrinic acid

Size Price Availability Quantity
5g USD 40  USD40 In stock
10g USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

Clofibric acid (PCIB, Chlorofibrinic acid), a lipid fiber modulator Clofibrate, Etofibrate and Etofyllinclofibrate active metabolites, is a PPARα excitant, has the effect of lowering blood lipid. Clofibric acid is also a herbicide.

Chemical Information
Molecular Weight 214.65
Formula C10H11ClO3
CAS Number 882-09-7
Solubility (25°C) DMSO 90 mg/mL
Ethanol 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] R Salgado, et al. Biodegradation of clofibric acid and identification of its metabolites

[2] Byounghoon Hwang, et al. Additive effects of clofibric acid and pyruvate dehydrogenase kinase isoenzyme 4 (PDK4) deficiency on hepatic steatosis in mice fed a high saturated fat diet

[3] Akihiko Hirose, et al. Clofibric acid increases the formation of oleic acid in endoplasmic reticulum of the liver of rats

[4] R Paxton, et al. Clofibric acid, phenylpyruvate, and dichloroacetate inhibition of branched-chain alpha-ketoacid dehydrogenase kinase in vitro and in perfused rat heart

[5] P J Meffin, et al. Reduced clofibric acid clearance in renal dysfunction is due to a futile cycle

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Keywords: Clofibric Acid (PCIB), 2-(4-Chlorophenoxy)-2-methylpropionic acid; Chlorofibrinic acid supplier, PPAR, inhibitors, activators

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