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GW7647

Cat. No. M2747
GW7647 Structure
Size Price Availability Quantity
5mg USD 120  USD120 In stock
10mg USD 180  USD180 In stock
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Quality Control & Documentation
Biological Activity

GW7647 is a potent and highly selective PPARα agonist with EC50 of 6 nM.

Product Citations
Chemical Information
Molecular Weight 502.75
Formula C29H46N2O3S
CAS Number 265129-71-3
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Xiao-Xia Qu, et al. PPAR-α Agonist GW7647 Protects Against Oxidative Stress and Iron Deposit via GPx4 in a Transgenic Mouse Model of Alzheimer's Diseases

[2] Rahul Patil, et al. A ligand-induced structural change in fatty acid-binding protein 1 is associated with potentiation of peroxisome proliferator-activated receptor α agonists

[3] Sophie E van der Krieken, et al. C/EBP-β Is Differentially Affected by PPARα Agonists Fenofibric Acid and GW7647, But Does Not Change Apolipoprotein A-I Production During ER-Stress and Inflammation

[4] Hsiang-Ying Lee, et al. PPAR-α and glucocorticoid receptor synergize to promote erythroid progenitor self-renewal

[5] Qin Liang, et al. A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses

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Keywords: GW7647 supplier, PPAR, inhibitors, activators


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