Inhibitor/Activator
| Cat.No. | Name | Information |
|---|---|---|
| M5940 | Rosiglitazone HCl | Rosiglitazone HCl is a hypoglycemic compound that stimulates insulin secretion by binding to PPAR receptors in fat cells. |
| M2748 | GW9662 | GW9662 is a selective PPAR antagonist for PPARγ with IC50 of 3.3 nM, with at least 100 to 1000-fold functional selectivity in cells with PPARγ versus PPARα and PPARδ. |
| M1880 | WY 14643 (Pirinixic Acid) | WY 14643 (Pirinixic Acid) is a potent and selective, peroxisome proliferator-activated receptor-α (PPARα) agonist. |
| M2335 | ZLN005 | ZLN005 is a novel and potent small molecule PGC-1α transcriptional activator. |
| M5878 | Pioglitazone HCl | Pioglitazone HCl is a selective peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist, used to treat diabetes. |
| M3283 | Pioglitazone | Pioglitazone (U 72107) is a selective peroxisome proliferator-activated receptor gamma stimulator. |
| M1894 | Rosiglitazone | Rosiglitazone (BRL 49653) is an orally active selective PPARγ agonist (EC50=60 nM, Kd=40 nM). Rosiglitazone is an TRPC5 activator (EC50=30 μM) and TRPM3 inhibitor. |
| M2747 | GW7647 | GW7647 is a potent and highly selective PPARα agonist with EC50 of 6 nM. |
| M6723 | Fenofibrate | Fenofibrate is a selective PPARα agonist with an EC50 of 30 μM. Fenofibrate inhibited cytochrome P450 subtype, with IC50 of 0.2, 0.7, 9.7, 4.8, and 142.1 μM for CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4, respectively. |
| M9747 | Lanifibranor | Lanifibranor (IVA-337) is a peroxisome proliferator-activated receptors (PPAR) agonist, with EC50s of 1.5, 0.87 and 0.21 μM for human PPARα, PPARσ and PPARγ, respectively. |
| M17212 | Raspberry ketone | Raspberry ketone shows PPAR-α agonistic activity. Raspberry ketone is a major aromatic compound of red raspberry, widely used as a fragrance in cosmetics and as a flavoring agent in foodstuff. |
| M13724 | Saroglitazar Magnesium | Saroglitazar magnesium is a novel peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity with EC50 values of 0.65 pM and 3 nM in HepG2 cells, respectively. |
| M13723 | GW1929 | GW1929 is a potent PPAR-γ agonist, with a pKi of 8.84 for human PPAR-γ, and pEC50s of 8.56 and 8.27 for human PPAR-γ and murine PPAR-γ, respectively. |
| M11257 | Alpinetin | Alpinetin is a flavonoid isolated from grass cardamom, which can activate PPAR-γ and has anti-inflammatory activity. |
| M11255 | DG172 dihydrochloride | DG172 dihydrochloride is a selective PPARβ/δ antagonist with an IC50 value of 27 nM. |
| M10513 | MA-0204 | MA-0204 is a highly potent and selective PPARδ modulator (PPARδ EC50 = 0.4 nM; PPARα, EC50 = 6,660 nM) that upregulates the expression of FAO genes in human renal proximal tubule cells, resulting in increased mitochondrial fatty acid oxidation. |
| M10453 | LY518674 | LY518674 is a potent and selective PPAR-alpha antagonist with EC50 of 42 nM for human PPARα. |
| M10245 | Pemafibrate | Pemafibrate is a potent and highly specific PPARα agonist, with EC50s of 1 nM, 1.10 μM and 1.58 μM for h-PPARα, h-PPARγ and h-PPARδ, respectively. |
| M10192 | Seladelpar sodium salt | Seladelpar (MBX-8025; RWJ-800025) sodium salt is a selective peroxisome proliferator-activated receptor (SPPAR) -δ receptor agonist. |
| M9802 | EHP-101 | EHP-101 (VCE-004.8) is an orally active, specific PPARγ and CB2 receptor dual agonist. |
| M9496 | Balaglitazone | Balaglitazone is an agonist of peroxisome proliferator-activated receptor (PPAR) γ, with an EC50 of 1.351 μM for human PPARγ. |
| M9476 | Elafibranor | Elafibranor (GFT505) is a potentially first-of-its-kind (first-in-class), orally active dual peroxisome-activated receptor (PPAR) α/δ agonist for studies related to primary biliary cirrhosis (PBC). |
| M9468 | SR-18292 | SR-18292 is a PPAR gamma coactivator-1α (PGC-1α) inhibitor, which increases PGC-1α acetylation, suppresses gluconeogenic gene expression. |
| M9195 | Saroglitazar | Saroglitazar is a novel peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity, with EC50 values of 0.65 pM and 3 nM in HepG2 cells, respectively. |
| M9048 | Etomoxir | Etomoxir is a potent inhibitor of carnitine palmitoyltransferase-I (CPT-1). |
| M8990 | LB-100 | LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor, with IC50 of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells. |
| M8154 | Mifobate | SR-202 is a selective PPARγ antagonist. |
| M7822 | Gemfibrozil | Gemzil is a PPAR-α activator, which is a lipid-lowering agent. Gemfibrozil is also a nonselective inhibitor of P450, with Ki values of 5.8, 24,69 and 82 μM for CYP2C9, 2C19, 2C8 and 1A2, respectively. |
| M6777 | GW 1929 hydrochloride | GW 1929 hydrochloride is a selective PPARγ agonist. Orally active. |
| M6602 | Ciglitazone | Ciglitazone is an effective selective PPARγ agonist (EC50=3 μM). Ciglitazone inhibited the proliferation and differentiation of TH17 cells. Ciglitazone is an oral hypoglycemic agent that has been shown to be active in obese hyperglycemic animal models. Ciglitazone induces apoptosis in opossum renal epithelial cells and simultaneously activates nuclear translocation of P38 MAPK and apoptosis-inducing factor (AIF). |
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