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Seladelpar (MBX-8025; RWJ-800025) sodium salt is a selective peroxisome proliferator-activated receptor (SPPAR) -δ receptor agonist. After intraperitoneal glucose injection, blood glucose reaches ~32 mM in vehicle-treated versus ~14 mM in Seladelpar-treated foz/foz mice (P<0.05); the area under the blood glucose disappearance curve is correspondingly lower in Seladelpar-treated foz/foz mice (P<0.05). Seladelpar produces a proportionally similar effect on glucose handling in atherogenic dietfed Wt mice (P<0.05).
| Molecular Weight | 466.45 |
| Formula | C21H22F3NaO5S |
| CAS Number | 3026272-26-1 |
| Solubility (25°C) | Water ≥ 90 mg/mL DMSO 47 mg/mL |
| Storage | 2-8°C, dry, sealed |
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