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Seladelpar sodium salt

Cat. No. M10192
Seladelpar sodium salt Structure
Synonym:

MBX-8025; RWJ-800025 sodium salt

Size Price Availability Quantity
10mg USD 147  USD147 In stock
25mg USD 295  USD295 In stock
50mg USD 480  USD480 In stock
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Quality Control
  • Current batch:
  • Purity >98.5%
  • COA
  • MSDS
Biological Activity

Seladelpar (MBX-8025; RWJ-800025) sodium salt is a selective peroxisome proliferator-activated receptor (SPPAR) -δ receptor agonist. After intraperitoneal glucose injection, blood glucose reaches ~32 mM in vehicle-treated versus ~14 mM in Seladelpar-treated foz/foz mice (P<0.05); the area under the blood glucose disappearance curve is correspondingly lower in Seladelpar-treated foz/foz mice (P<0.05). Seladelpar produces a proportionally similar effect on glucose handling in atherogenic dietfed Wt mice (P<0.05).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 466.45
Formula C21H22F3NaO5S
CAS Number 851528-79-5 (free base)
Purity >98.5%
Solubility DMSO ≥ 30 mg/mL
Storage 2-8°C, dry, sealed
References

[1] Fahrettin Haczeyni, et al. Hepatol Commun. The selective peroxisome proliferator-activated receptor-delta agonist seladelpar reverses nonalcoholic steatohepatitis pathology by abrogating lipotoxicity in diabetic obese mice

[2] Amirhossein Sahebkar, et al. Expert Opin Pharmacother. New peroxisome proliferator-activated receptor agonists: potential treatments for atherogenic dyslipidemia and non-alcoholic fatty liver disease

[3] Yun-Jung Choi, et al. Atherosclerosis. Effects of the PPAR-δ agonist MBX-8025 on atherogenic dyslipidemia

[4] Harold E Bays, et al. J Clin Endocrinol Metab. MBX-8025, a novel peroxisome proliferator receptor-delta agonist: lipid and other metabolic effects in dyslipidemic overweight patients treated with and without atorvastatin

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Keywords: Seladelpar sodium salt, MBX-8025; RWJ-800025 sodium salt supplier, PPAR, inhibitors

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