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Seladelpar sodium salt

Cat. No. M10192
Seladelpar sodium salt Structure
Synonym:

MBX-8025; RWJ-800025 sodium salt

Size Price Availability Quantity
10mg USD 147  USD147 In stock
25mg USD 295  USD295 In stock
50mg USD 480  USD480 In stock
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Quality Control & Documentation
Biological Activity

Seladelpar (MBX-8025; RWJ-800025) sodium salt is a selective peroxisome proliferator-activated receptor (SPPAR) -δ receptor agonist. After intraperitoneal glucose injection, blood glucose reaches ~32 mM in vehicle-treated versus ~14 mM in Seladelpar-treated foz/foz mice (P<0.05); the area under the blood glucose disappearance curve is correspondingly lower in Seladelpar-treated foz/foz mice (P<0.05). Seladelpar produces a proportionally similar effect on glucose handling in atherogenic dietfed Wt mice (P<0.05).

Chemical Information
Molecular Weight 466.45
Formula C21H22F3NaO5S
CAS Number 851528-79-5 (free base)
Solubility (25°C) DMSO ≥ 30 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Fahrettin Haczeyni, et al. Hepatol Commun. The selective peroxisome proliferator-activated receptor-delta agonist seladelpar reverses nonalcoholic steatohepatitis pathology by abrogating lipotoxicity in diabetic obese mice

[2] Amirhossein Sahebkar, et al. Expert Opin Pharmacother. New peroxisome proliferator-activated receptor agonists: potential treatments for atherogenic dyslipidemia and non-alcoholic fatty liver disease

[3] Yun-Jung Choi, et al. Atherosclerosis. Effects of the PPAR-δ agonist MBX-8025 on atherogenic dyslipidemia

[4] Harold E Bays, et al. J Clin Endocrinol Metab. MBX-8025, a novel peroxisome proliferator receptor-delta agonist: lipid and other metabolic effects in dyslipidemic overweight patients treated with and without atorvastatin

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Keywords: Seladelpar sodium salt, MBX-8025; RWJ-800025 sodium salt supplier, PPAR, inhibitors, activators


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