Inhibitor/Activator
| Cat.No. | Name | Information |
|---|---|---|
| M5940 | Rosiglitazone HCl | Rosiglitazone HCl is a hypoglycemic compound that stimulates insulin secretion by binding to PPAR receptors in fat cells. |
| M2748 | GW9662 | GW9662 is a selective PPAR antagonist for PPARγ with IC50 of 3.3 nM, with at least 100 to 1000-fold functional selectivity in cells with PPARγ versus PPARα and PPARδ. |
| M1880 | WY 14643 (Pirinixic Acid) | WY 14643 (Pirinixic Acid) is a potent and selective, peroxisome proliferator-activated receptor-α (PPARα) agonist. |
| M2335 | ZLN005 | ZLN005 is a novel and potent small molecule PGC-1α transcriptional activator. |
| M5878 | Pioglitazone HCl | Pioglitazone HCl is a selective peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist, used to treat diabetes. |
| M3283 | Pioglitazone | Pioglitazone (U 72107) is a selective peroxisome proliferator-activated receptor gamma stimulator. |
| M1894 | Rosiglitazone | Rosiglitazone (BRL 49653) is an orally active selective PPARγ agonist (EC50=60 nM, Kd=40 nM). Rosiglitazone is an TRPC5 activator (EC50=30 μM) and TRPM3 inhibitor. |
| M2747 | GW7647 | GW7647 is a potent and highly selective PPARα agonist with EC50 of 6 nM. |
| M6723 | Fenofibrate | Fenofibrate is a selective PPARα agonist with an EC50 of 30 μM. Fenofibrate inhibited cytochrome P450 subtype, with IC50 of 0.2, 0.7, 9.7, 4.8, and 142.1 μM for CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4, respectively. |
| M9747 | Lanifibranor | Lanifibranor (IVA-337) is a peroxisome proliferator-activated receptors (PPAR) agonist, with EC50s of 1.5, 0.87 and 0.21 μM for human PPARα, PPARσ and PPARγ, respectively. |
| M5530 | Clofibrate | Clofibrate (Atromid-S), a fibric acid derivative used in the treatment of hyperlipoproteinemia type III and severe hypertriglyceridemia. |
| M5171 | Troglitazone (CS-045) | Troglitazone is a potent agonist for the peroxisome proliferator-activated receptor-(PPAR) that is a ligand activated transcription factor regulating cell differentiation and growth. |
| M5150 | Glimepiride | Glimepiride (Glimperide; HOE-490) is a medium-to-long acting sulfonylurea anti-diabetic compound with an ED50 of 182 μg/kg. |
| M5125 | BMS-687453 | Bms-687453 is an effective and selective PPARα agonist with EC50 and IC50 of 10 nM and 260 nM for human PPARα, respectively. The EC50 and IC50 values were 4100 nM and >15000 nM, respectively. |
| M4778 | Apo-12’-lycopenal | Apo-12’-lycopenal |
| M4751 | 5,7-dihydroxychromone | 5,7-dihydroxychromone is a natural antioxidant extracted from plants, it acts as an Nrf2/ARE signal activator or a PPARγ agonist. |
| M4469 | Cinnamaldehyde | Cinnamaldehyde is a naturally occurring flavonoid found in the bark of Cinnamomum cinnamomi and other Cinnamomum species such as camphor and cinnamon, and can act through a variety of signaling pathways, including PPARs, AMPK, PI3K/IRS-1, RBP4-GLUT4, ERK/JNK/p38MAPK, TRPA1-ghrelin, and the Nrf2 pathways.Cinnamaldehyde also has the potential to modulate the activities of PTP1B and α-amylase with antifungal activity and antioxidant activity. |
| M4468 | Cinnamyl-alcohol | Cinnamyl Alcohol isolated from Chestnut flower showed anti-obesity activity by inhibiting the expression of PPARγ. |
| M4372 | Gypenoside XLIX | Gypenoside XLIX is a dammarane-type glycoside, the main constituent of G. pentaphyllum. Gypenoside XLIX is a selective PPAR-α activator that inhibits cytokine-induced VCAM-1 overexpression in human endothelial cells and hyperactive. |
| M4352 | (-)-Licarin-B | Licarin B, derived from the seed of Myristica Fragrans, is an inhibitor of NO production that improves insulin sensitivity by activating PPARγ and GLUT4 in the IRS-1/PI3K/AKT pathway. |
| M4275 | Oleuropein | Oleuropein, found in olive leaves and oils, exerts antioxidant, anti-inflammatory and antiatherosclerotic effects by directly inhibiting PPARγ transcriptional activity. Oleuropein induces apoptosis of breast cancer cells through p53-dependent pathways and regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase. |
| M4261 | Angeloyl-gomisin-H | Angeloylgomisin H isa lignan compound available from Schisandra rubriflora. Angeloylgomisin H improves insulin - stimulated glucose uptake potential by activating PPAR-γ. |
| M4154 | Soyosaponin-Aa | Soyasaponin Aa is a soy saponin that exerts anti-obesity effects by down-regulating PPARγ in 3T3-L1 adipocytes. |
| M4147 | Astaxanthin | Astaxanthin is a modulator of PPARγ and a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity. *This compound is unstable in solutions, freshly prepared is recommended. |
| M4131 | Ophiopogonin-D | Ophiopogonin D, isolated from the tuber of Ophiopogon japonicus, is a rare naturally occurring C29 steroid glycoside. Ophiopogonin D is a CYP2J3 inducer. By increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs), Ophiopogonin D significantly inhibited Ang Ii-induced NF-κB nuclear translocation and IκBα down-regulation. Intracellular Ca2+ overload and activation of pro-inflammatory cytokines. |
| M4069 | (S)Ginsenoside-Rh1 | Ginsenoside Rh1 (Prosapogenin A2) inhibited the expression of PPAR-γ, TNF-α, IL-6 and IL-1β. |
| M3939 | Eupatilin | Eupatilin is a lipophile flavonoid extracted from Artemisia. It is a PPARα agonist with anti-apoptosis, anti-oxidation and anti-inflammation effects. |
| M3658 | GW501516 | GW501516 is a potent and highly selective PPARβ/δ agonist, with EC50 of 1 nM, with 1000-fold selectivity over hPPARα and hPPARγ. |
| M3635 | FH535 | FH535 is a compound that suppresses both Wnt/beta-catenin and peroxisome proliferator-activated receptor (PPAR) signaling. |
| M3044 | T0070907 | T0070907 is a potent and selective PPARγ inhibitor with IC50 of 1 nM, with a >800-fold selectivity over PPARα and PPARδ. |
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