Bms-687453 is an effective and selective PPARα agonist with EC50 and IC50 of 10 nM and 260 nM for human PPARα, respectively. The EC50 and IC50 values were 4100 nM and >15000 nM, respectively.
| Molecular Weight | 444.86 |
| Formula | C22H21ClN2O6 |
| CAS Number | 1000998-59-3 |
| Form | Solid |
| Solubility (25°C) | DMSO > 31 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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