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Ophiopogonin-D

Cat. No. M4131
Ophiopogonin-D Structure
Synonym:

65604-80-0; 945619-74-9

Size Price Availability Quantity
5mg USD 165  USD165 In stock
10mg USD 215  USD215 In stock
20mg USD 330  USD330 In stock
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Quality Control & Documentation
Biological Activity

Ophiopogonin D, isolated from the tuber of Ophiopogon japonicus, is a rare naturally occurring C29 steroid glycoside. Ophiopogonin D is a CYP2J3 inducer. By increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs), Ophiopogonin D significantly inhibited Ang Ii-induced NF-κB nuclear translocation and IκBα down-regulation. Intracellular Ca2+ overload and activation of pro-inflammatory cytokines.

Chemical Information
Molecular Weight 855.02
Formula C44H70O16
CAS Number 945619-74-9
Solubility (25°C) 10 mM in DMSO
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Xiang-Lin Tang, et al. Effects of ophiopogonin D on fatty acid metabolic enzymes in cardiomyocytes

[2] Weiwei Li, et al. Ophiopogonin D alleviates diabetic myocardial injuries by regulating mitochondrial dynamics

[3] Xue Zhu, et al. Ophiopogonin D suppresses TGF-β1-mediated metastatic behavior of MDA-MB-231 breast carcinoma cells via regulating ITGB1/FAK/Src/AKT/β-catenin/MMP-9 signaling axis

[4] Mi Yang, et al. Ophiopogonin D promotes bone regeneration by stimulating CD31 hi EMCN hi vessel formation

[5] Eun-Jin An, et al. Ophiopogonin D ameliorates DNCB-induced atopic dermatitis-like lesions in BALB/c mice and TNF-α- inflamed HaCaT cell

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Keywords: Ophiopogonin-D, 65604-80-0; 945619-74-9 supplier, PPAR, inhibitors, activators


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